Dietary modulation of the human gut microflora using the prebiotics oligofructose and inulin
Dietary modulation of the human gut microflora using the prebiotics oligofructose and inulin
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DOI：
10.1093/jn/129.7.1438s
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发表时间：
1999-07-01
影响因子：
4.2
通讯作者：
Gibson, GR
中科院分区：
文献类型：
--
作者：
Gibson, GR
尽管在人类中很大程度上尚未得到证实，但通过肠道微生物群的控制，可能可以更好地抵抗病原体、降低血脂、抗肿瘤特性、激素调节和免疫刺激。一种方法提倡口服活微生物（益生菌）。尽管益生菌方法已被广泛使用和提倡，但摄入后的存活率/活力很难保证，几乎不可能证明。益生元概念规定，非活性膳食成分可以强化肠道菌群的某些成分（例如双歧杆菌、乳酸杆菌）。这个概念的优点是，通过上胃肠道摄入的成分的存活不是先决条件，因为它是针对的本地细菌属。给人类志愿者喂食低聚果糖和菊粉会改变肠道菌群组成，有利于双歧杆菌（据称是有益的菌属）。未来利用现代分子细菌检测方法进行的人体研究将确定益生元的功效。通过选择性靶向肠道细菌，可能可以预防性地解决某些胃肠道疾病。
Although largely unproven in humans, better resistance to pathogens, reduction in blood lipids, antitumor properties, hormonal regulation and immune stimulation may all be possible through gut microflora manipulation. One approach advocates the oral intake of live microorganisms (probiotics). Although the probiotic approach has been extensively used and advocated, survivability/viability after ingestion is difficult to guarantee and almost impossible to prove. The prebiotic concept dictates that non viable dietary components fortify certain components of the intestinal flora (e.g., bifidobacteria, lactobacilli). This concept has the advantage that survival of the ingested ingredient-through the upper gastrointestinal tract is not a prerequisite because it is indigenous bacterial genera that are targeted. The feeding of oligofructose and inulin to human volunteers alters the gut flora composition in favor of bifidobacteria, a purportedly beneficial genus. Future human studies that exploit the use of modern molecular-based detection methods for bacteria will determine the efficacy of prebiotics. It may be possible to address prophylactically certain gastrointestinal complaints through the selective targeting of gut bacteria.