American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies
American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies
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DOI：
10.1002/jbmr.3839
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发表时间：
2019-09-23
影响因子：
6.2
通讯作者：
Schwarz, Edward M.
中科院分区：
文献类型：
--
作者：
O'Keefe, Regis J.;Tuan, Rocky S.;Schwarz, Edward M.
基于细胞的疗法，在这里被定义为在体内递送细胞以治疗疾病，作为恢复肌肉骨骼组织的结构和功能的潜在有前途的方法，最近越来越受到公众的关注。虽然基于细胞的治疗有可能改善肌肉骨骼系统疾病的治疗，但也有可能误用和歪曲这种治疗的疗效。医学文献包含轶事报告和研究，沿着基于网络的营销和支持基于细胞的治疗的患者推荐。美国骨与矿物质研究学会（ASBMR）和骨科研究学会（ORS）都致力于确保通过严谨、可重复且具有临床意义的科学发现来实现细胞疗法的潜力。这两个组织召集了一个多学科的国际工作组，由医生、外科医生和科学家组成，他们是开发和使用细胞疗法的公认专家。该工作组负责确定基于细胞的疗法的最新技术水平，并确定应指导研究议程的知识和方法的差距。该工作组的工作旨在为研究人员和临床医生提供更好地了解当前的科学和研究状况，以推进骨骼组织细胞疗法的研究和使用。设计和实施严格、全面的方案对于利用这些创新治疗和优化临床和功能性患者结局至关重要。除了为临床前和临床研究提供具体的建议和伦理考虑外，本报告还总结了如何确定用于骨再生的供体群体的细胞自主和非自主效应的知识差距。(c)2019年美国骨与矿物质研究学会。
Cell-based therapies, defined here as the delivery of cells in vivo to treat disease, have recently gained increasing public attention as a potentially promising approach to restore structure and function to musculoskeletal tissues. Although cell-based therapy has the potential to improve the treatment of disorders of the musculoskeletal system, there is also the possibility of misuse and misrepresentation of the efficacy of such treatments. The medical literature contains anecdotal reports and research studies, along with web-based marketing and patient testimonials supporting cell-based therapy. Both the American Society for Bone and Mineral Research (ASBMR) and the Orthopaedic Research Society (ORS) are committed to ensuring that the potential of cell-based therapies is realized through rigorous, reproducible, and clinically meaningful scientific discovery. The two organizations convened a multidisciplinary and international Task Force composed of physicians, surgeons, and scientists who are recognized experts in the development and use of cell-based therapies. The Task Force was charged with defining the state-of-the art in cell-based therapies and identifying the gaps in knowledge and methodologies that should guide the research agenda. The efforts of this Task Force are designed to provide researchers and clinicians with a better understanding of the current state of the science and research needed to advance the study and use of cell-based therapies for skeletal tissues. The design and implementation of rigorous, thorough protocols will be critical to leveraging these innovative treatments and optimizing clinical and functional patient outcomes. In addition to providing specific recommendations and ethical considerations for preclinical and clinical investigations, this report concludes with an outline to address knowledge gaps in how to determine the cell autonomous and nonautonomous effects of a donor population used for bone regeneration. (c) 2019 American Society for Bone and Mineral Research.