Novel gastrointestinal disease in common marmosets characterised by duodenal dilation: a clinical and pathological study
Novel gastrointestinal disease in common marmosets characterised by duodenal dilation: a clinical and pathological study
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DOI：
10.1038/s41598-020-60398-4
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发表时间：
2020-03-02
影响因子：
4.6
通讯作者：
Sasaki, Erika
中科院分区：
文献类型：
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作者：
Mineshige, Takayuki;Inoue, Takashi;Sasaki, Erika
普通绒猴（Callithrix jacchus）经常用于生物医学研究，但胃肠道疾病一直是维持圈养绒猴的主要健康问题。我们已经诊断出一种新的胃肠道疾病的绒猴，我们建议称之为“绒猴十二指肠扩张综合征”，这种疾病的特点是近端十二指肠梗阻和扩张。本研究旨在揭示该综合征的临床和病理表现，并建立合适的影像学诊断方法。在日本川崎的实验动物中央研究所，患有该综合征的动物占尸检病例的21.9%。该综合征的特征是临床体征，包括呕吐，腹胀和体重减轻。大体上，所有患病动物均表现出十二指肠降部显著扩张，其中含有气体和液体的混合物。通过造影剂X线检查明确诊断十二指肠扩张。此外，平片和超声检查相结合被认为是一个可行的筛选方法诊断十二指肠扩张。十二指肠扩张的动物特征性地表现出十二指肠降段和升结肠之间的粘连，并伴有慢性腹膜炎。绒猴十二指肠扩张综合征的原因尚不清楚，但可能是多因素的，包括本研究中的腹膜粘连、慢性溃疡和喂养条件。
Common marmosets (Callithrix jacchus) are frequently used for biomedical research but gastrointestinal diseases have been major health problems to maintain captive marmosets. We have diagnosed a novel gastrointestinal disease in marmosets, as which we propose to call 'marmoset duodenal dilation syndrome'; this disease is characterised by proximal duodenal obstruction and dilation. This study aimed to reveal the clinical and pathological findings of this syndrome and establish appropriate diagnostic imaging methods. Animals with the syndrome comprised 21.9% of the necropsy cases at the Central Institute for Experimental Animals in Kawasaki, Japan. The syndrome is characterised by clinical signs included vomiting, bloating, and weight loss. Grossly, all diseased animals exhibited significant dilation of the descending part of the duodenum, which contained a mixture of gas and fluid. The duodenal dilations were definitively diagnosed by contrast radiography. Moreover, a combination of plain radiography and ultrasonography was found to be a viable screening method for diagnosing duodenal dilation. The animals with duodenal dilation characteristically showed adhesions between the descending duodenum and ascending colon with chronic peritonitis. The cause of marmoset duodenal dilation syndrome remains unknown, but was likely multifactorial, including peritoneal adhesion, chronic ulcer, and feeding conditions in this study.