TUMOR-INITIATING ACTIVITY IN MOUSE SKIN AND CARCINOGENICITY IN RAT MAMMARY-GLAND OF DIBENZO[A]PYRENES - THE VERY POTENT ENVIRONMENTAL CARCINOGEN DIBENZO[A,L]PYRENE
TUMOR-INITIATING ACTIVITY IN MOUSE SKIN AND CARCINOGENICITY IN RAT MAMMARY-GLAND OF DIBENZO[A]PYRENES - THE VERY POTENT ENVIRONMENTAL CARCINOGEN DIBENZO[A,L]PYRENE
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DOI：
10.1007/bf00391602
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发表时间：
1989-01-01
影响因子：
3.6
通讯作者：
SALMASI, S
中科院分区：
文献类型：
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作者：
CAVALIERI, EL;ROGAN, EG;SALMASI, S
对几种二苯并[a]-芘（DBP）在小鼠皮肤中的肿瘤引发活性和在大鼠乳腺中的致癌性进行了比较研究。 SENCAR小鼠用DB[a,e]P、DB[a,h]P、DB[a,i]P、DB[a,l]P和蒽蒽起始，并用十四烷酰佛波醇乙酸酯促进。通过乳头内注射对雌性 Sprague-Dawley 大鼠测试相同的化合物。蒽醌在小鼠皮肤和大鼠乳腺中均无活性。 DB[a,e]P 在小鼠皮肤中是一种非常弱的肿瘤引发剂，在大鼠乳腺中没有活性。 DB[a,h]P 在小鼠皮肤中诱导的乳头状瘤数量是 DB[a,i]P 的两倍，尽管这两种化合物表现出相似的肿瘤潜伏期和荷瘤小鼠的百分比。这两种化合物诱导的乳腺肿瘤数量相似，但用 DB[a,i]P 治疗大鼠导致腺癌数量显着增加。 DB[a,l]P 对小鼠和大鼠均有毒。用这种化合物治疗小鼠皮肤会导致红斑，从而将推广的开始推迟到开始后的第三周。尽管存在这种延迟，但在开始使用 DB[a,l]P 后 5 周，乳头状瘤开始出现，并且肿瘤数量迅速增加。该化合物对大鼠的毒性很大，以至于一半的动物在前 9 周内死亡，其余的动物在 15 周后被处死。尽管如此，DB[a,l]P 是测试中最强的致癌物，每只大鼠在 10 周内诱发 7 个肿瘤。这些结果表明，烟草烟雾中存在的 DB[a,l]P 是一种极强的致癌芳香烃。此外，其中一些化合物可以作为阐明其激活机制的有用模型。
Comparative studies of tumor-initiating activity in mouse skin and carcinogenicity in rat mammary gland were conducted with several dibenzo[a]-pyrenes (DBPs). SENCAR mice were initiated with DB[a,e]P, DB[a,h]P, DB[a,i]P, DB[a,l]P and anthanthrene, and promoted with tetradecanoyl-phorbol acetate. The same compounds were tested by intramammillary injection in female Sprague-Dawley rats. Anthanthrene was inactive in both in both mouse skin and rat mammary gland. DB[a,e]P was a very weak tumor-initiator in mouse skin and was inactive in rat mammary gland. DB[a,h]P induced twice as many papillomas in mouse skin as DB[a,i]P, although both compounds exhibited similar tumor latencies and percentages of tumor-bearing mice. These two compounds induced similar numbers of mammary tumors but treatment of the rats with DB[a,i]P resulted in a significantly larger number of adenocarcinomas. DB[a,l]P was toxic to both the mice and rats. Treatment of mouse skin with this compound led to an erytherma, which delayed the beginning of promotion until the 3rd week after initiation. Despite this delay, papillomas began appearing 5 weeks after initiation with DB[a,l]P and the number of tumors increased rapidly. The compound was so toxic in the rats that half of the animals died in the first 9 weeks and the remaining animals were sacrificed after 15 weeks. Nonetheless, DB[a,l]P was the strongest carcinogen tested, inducing seven tumors per rat within 10 weeks. These results demonstrate that DB[a,l]P, which is present in tobacco smoke, is an extremely potent carcinogenic aromatic hydrocarbon. Furthermore, some of these compounds can serve as useful models for elucidating their mechanisms of activation.