Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter
Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter
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DOI：
10.1364/ol.42.000379
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发表时间：
2017-02-01
期刊：
影响因子：
3.6
通讯作者：
Yoo, Hongki
中科院分区：
文献类型：
--
作者：
Kim, Junyoung;Xing, Jingchao;Yoo, Hongki
显微光学相干层析成像(MU-OCT)是一种先进的成像技术，它利用宽带光源和大数值孔径(NA)透镜获得高空间分辨率的生物样品的三维微结构，分辨率高达1微米。由于高NA会产生较短的焦深(DOF)，因此有必要延长DOF以获得合理的成像深度。然而，由于光学系统的复杂性和有限的空间，内窥镜MUOCT的制作一直是一个挑战，这是临床翻译所必需的。在这里，我们报告了一种使用二进制相位空间滤波器的扩展自由度的内窥镜MUOCT探头。乳胶珠的成像结果表明，MUOCT探头的轴向分辨率为2.49微米，横向分辨率为2.59微米，自由度扩展2倍。通过对兔髂动脉的体外成像，证明了其临床应用的可行性。(C)2017年美国光学学会。
Micro-optical coherence tomography (mu OCT) is an advanced imaging technique that acquires a three-dimensional microstructure of biological samples with a high spatial resolution, up to 1 mu m, by using a broadband light source and a high numerical aperture (NA) lens. As high NA produces a short depth of focus (DOF), extending the DOF is necessary to obtain a reasonable imaging depth. However, due to the complexity of optics and the limited space, it has been challenging to fabricate endoscopic mu OCT, which is essential for clinical translation. Here, we report an endoscopic mu OCT probe with an extended DOF by using a binary phase spatial filter. The imaging results from latex beads demonstrated that the mu OCT probe achieved an axial resolution of 2.49 mu m and a lateral resolution of 2.59 mu m with a DOF extended by a factor of 2. The feasibility of clinical use was demonstrated by ex vivo imaging of the rabbit iliac artery. (C) 2017 Optical Society of America.