Convergent evolution of gene networks by single-gene duplications in higher eukaryotes
Convergent evolution of gene networks by single-gene duplications in higher eukaryotes
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DOI：
10.1038/sj.embor.7400096
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发表时间：
2004-03-01
期刊：
影响因子：
7.7
通讯作者：
Bornberg-Bauer, E
中科院分区：
文献类型：
--
作者：
Amoutzias, GD;Robertson, DL;Bornberg-Bauer, E
通过结合系统发育、蛋白质组学和结构信息，我们阐明了基本螺旋-环-螺旋转录因子的基因-调控相互作用网络的进化驱动力。我们推测，重复发生的单基因复制和结构域重排事件导致了具有几乎相同的基于集线器的拓扑结构的不同网络，以及多个激活因子和抑制因子。因此，我们为通过单基因复制出现的无尺度蛋白质网络、分子模块化在自下而上构建复杂生物实体中的主导作用以及网络的收敛进化提供了第一个经验证据。
By combining phylogenetic, proteomic and structural information, we have elucidated the evolutionary driving forces for the gene-regulatory interaction networks of basic helix-loop-helix transcription factors. We infer that recurrent events of single-gene duplication and domain rearrangement repeatedly gave rise to distinct networks with almost identical hub-based topologies, and multiple activators and repressors. We thus provide the first empirical evidence for scale-free protein networks emerging through single-gene duplications, the dominant importance of molecular modularity in the bottom-up construction of complex biological entities, and the convergent evolution of networks.