Incidence and clinical correlation of anticentromere antibody in Thai patients
Incidence and clinical correlation of anticentromere antibody in Thai patients
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DOI：
10.1007/s10067-005-0005-4
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发表时间：
2006-05-01
影响因子：
3.4
通讯作者：
Janwityanujit, S
中科院分区：
文献类型：
--
作者：
Pakunpanya, K;Verasertniyom, O;Janwityanujit, S
抗着丝粒抗体（ACA）可用于评估和分类患有系统性硬化症的轻度变体（称为钙质沉着、雷诺现象、食管动力障碍、指硬化、毛细血管扩张（CREST）综合征）的患者。从他们的预后意义，我们有兴趣在泰国患者的患病率和疾病的相关性。1998年至2001年期间，共有3 233名有任何肌肉骨骼症状的患者的血清样本被送往Ramathibodi免疫学实验室服务处进行抗核抗体测定。ACA阳性40例（1.23%）。这些血清来自27例自身免疫性疾病和13例非自身免疫性疾病患者。在自身免疫组中，硬皮病是最常见的诊断（33.3%），局限性硬化是最常见的变异。低滴度（1：40）和高滴度（1：640）组中自身免疫性疾病的百分比几乎相同。该研究表明，泰国患者中ACA的患病率较低。在肌肉骨骼症状模糊的患者中检测到ACA的存在并不意味着CREST综合征的诊断。即使是高滴度ACA也可以在非自身免疫性疾病中发现。
Anticentromere antibodies (ACA) are useful in assessing and classifying patients with mild variant of systemic sclerosis called calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias (CREST) syndrome. From their prognostic significance, we are interested in the prevalence and disease correlation in Thai patients. A total of 3,233 serum samples of patients with any musculoskeletal symptoms were sent for antinuclear antibody determination at Ramathibodi Immunology Laboratory Service between the years 1998 and 2001. Forty sera (1.23%) were ACA positive. These sera were from 27 patients with autoimmune diseases and 13 with nonautoimmune diseases. Among autoimmune group, scleroderma was the most common diagnosis (33.3%) with limited sclerosis being the most frequent variant. The percentages of autoimmune disease were almost the same among the low-titer (1:40) and the high-titer (1:640) groups. The study suggests that the prevalence of ACA in Thai patients is low. The presence of ACA detected in patients with vague musculoskeletal symptoms does not suggest a diagnosis of CREST syndrome. Even high-titer ACA can be found in nonautoimmune diseases.