Anti-Candida activity and chemical composition of Cinnamomum zeylanicum blume essential oil
Anti-Candida activity and chemical composition of Cinnamomum zeylanicum blume essential oil
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DOI：
10.1590/s1516-89132013000500005
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发表时间：
2013-10-01
影响因子：
1
通讯作者：
Lima, Edeltrudes Oliveira
中科院分区：
文献类型：
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作者：
Castro, Ricardo Dias de;Lima, Edeltrudes Oliveira
本研究的目的是确定肉桂精油（EO）的抗念珠菌活性和化学成分。为此，进行测试以确定最小抑制浓度（MIC）和最小杀真菌浓度（MFC）以及C. zeylanicum EO对白色念珠菌、C.和C.克柔氏菌株。通过气相色谱-质谱联用分析了其组成。EO对受试菌株具有显著的抗真菌活性，在MIC为312.5 μ g/mL和MFC为2500 μ g/mL时，敏感性分别为87.5%和62.5%。在山梨醇存在下，对所有菌株的MIC为625 μ g/mL，表明EO对真菌细胞壁可能有作用。丁香酚（73.27%）和反式-β-香芹烯（5.38%）的浓度较高。结果表明，所分析的EO具有抗念珠菌活性，并表明其发生是由于对真菌细胞壁的作用。
The purpose of this study was to identify the anti-Candida activity and chemical composition of the essential oil (EO) of Cinnamomum zeylanicum (cinnamon). For this, tests were conducted to determine the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) and the action of C. zeylanicum EO on fungal cell wall of Candida albicans, C. tropicalis and C. krusei strains. The composition of the was analysed by gas chromatography with mass spectrometry. Significant antifungal activity of the EO was observed on the strains tested, with 87.5% and 62.5% of them sensitive, respectively at a MIC of 312.5 mu g/mL and MFC of 2500 mu g/mL. In the presence of sorbitol, the MIC was 625 mu g/mL against all the strains, showing a possible action of the EO on fungal cell wall. Eugenol (73.27%) and trans-beta-caryophyllene (5.38%) were found in higher concentrations. The results indicated anti-Candida activity of the EO analyzed and suggested that it occurred due to the action on fungal cell wall.