Epidermal Growth Factor Receptor (EGFR) Crosstalks in Liver Cancer.
Epidermal Growth Factor Receptor (EGFR) Crosstalks in Liver Cancer.
复制标题
肝癌中表皮生长因子受体（EGFR）串扰。
DOI：
10.3390/cancers3022444
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发表时间：
2011-05-18
期刊：
影响因子：
5.2
通讯作者：
Avila MA
中科院分区：
文献类型：
--
作者：
Berasain C;Ujue Latasa M;Urtasun R;Goñi S;Elizalde M;Garcia-Irigoyen O;Azcona M;Prieto J;Avila MA
肝癌发生是一个复杂的多步骤过程，其中涉及许多不同的分子途径。肝细胞癌（HCC）对传统化疗药物难以治疗，而新的靶向治疗取得的成功有限。受体间串扰和不同信号系统之间的正反馈正在成为靶向治疗耐药的机制。因此，识别这种相互作用对于提高治疗效果特别重要。在肝癌发生过程中激活的不同信号通路中，表皮生长因子受体（EGFR）系统发挥着重要作用，被认为是不同细胞外生长和生存信号汇聚的“信号枢纽”。 EGFR 可以通过与多个受体的物理相互作用、细胞内激酶的活性或 EGFR 配体的脱落来响应多个异源配体而被反式激活。在本文中，我们回顾了 EGFR 和其他可能与肝癌发展和治疗相关的信号通路之间的串扰。
Hepatocarcinogenesis is a complex multistep process in which many different molecular pathways have been implicated. Hepatocellular carcinoma (HCC) is refractory to conventional chemotherapeutic agents, and the new targeted therapies are meeting with limited success. Interreceptor crosstalk and the positive feedback between different signaling systems are emerging as mechanisms of targeted therapy resistance. The identification of such interactions is therefore of particular relevance to improve therapeutic efficacy. Among the different signaling pathways activated in hepatocarcinogenesis the epidermal growth factor receptor (EGFR) system plays a prominent role, being recognized as a “signaling hub” where different extracellular growth and survival signals converge. EGFR can be transactivated in response to multiple heterologous ligands through the physical interaction with multiple receptors, the activity of intracellular kinases or the shedding of EGFR-ligands. In this article we review the crosstalk between the EGFR and other signaling pathways that could be relevant to liver cancer development and treatment.