Passive smoking and sudden infant death syndrome: review of the epidemiological evidence
Passive smoking and sudden infant death syndrome: review of the epidemiological evidence
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DOI：
10.1136/thx.52.11.1003
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发表时间：
1997-11-01
期刊：
影响因子：
10
通讯作者：
Cook, DG
中科院分区：
文献类型：
--
作者：
Anderson, HR;Cook, DG
背景-本文提供了一个系统的，定量的流行病学证据有关的父母吸烟和婴儿猝死的审查。方法-三十二个相关的出版物被确定后，考虑到692篇文章的Embase和Medline数据库的电子搜索，使用关键字和网状标题相关的被动吸烟的儿童。通过综述和与作者交谈，进一步确定了11篇文章。搜索完成于1997年4月，并确定了39 study.Results -未调整的合并优势比产前母亲吸烟为2.77（95%CI 2.45至3.13）。校正各种混杂因素后，合并优势比降至2.08（95%CI 1.83 - 2.38），队列研究和病例对照研究相似。4项研究报告了在控制产前母亲吸烟后母亲产后吸烟的情况（合并优势比1.94（95% CI 1.55 - 2.43））。在三项关于父亲吸烟风险的研究中，母亲是非吸烟者，其中两项发现了显着影响，而一项没有发现影响。剂量反应关系与产前和产后产妇吸烟目前在大多数研究提供data.Conclusions -产妇吸烟的婴儿猝死综合征的风险增加一倍。这种关系几乎可以肯定是因果关系。有充分的证据表明，出生后暴露于来自母亲和父亲的环境烟草烟雾是重要的。由于产前吸烟几乎总是与产后吸烟有关，因此产前吸烟本身的作用很难通过流行病学研究来解决。
Background - This paper provides a systematic, quantitative review of the epidemiological evidence relating parental smoking and sudden infant death.Methods - Thirty two relevant publications were identified after consideration of 692 articles selected by electronic search of the Embase and Medline databases using keywords and Mesh headings relevant to passive smoking in children. Eleven further articles were identified from reviews and by talking to authors. The search was completed in April 1997 and identified 39 studies.Results - The unadjusted pooled odds ratio for prenatal maternal smoking was 2.77 (95% CI 2.45 to 3.13). After adjustment for a variety of confounders the pooled odds ratio was reduced to 2.08 (95% CI 1.83 to 2.38) and was similar in cohort and case-control studies. Four studies reported on maternal postnatal smoking after controlling for prenatal maternal smoking (pooled odds ratio 1.94 (95% CI 1.55 to 2.43)). Of three studies reporting on the risk of paternal smoking where the mother was a non-smoker, two found significant effects while one found no effect. Dose-response relationships with both prenatal and postnatal maternal smoking were present in most studies which provided data.Conclusions - Maternal smoking doubles the risk of sudden infant death syndrome. The relationship is almost certainly causal. There is good evidence that postnatal exposure to environmental tobacco smoke fi om both mother and father are important. Because prenatal smoking is almost invariably associated with postnatal smoking, the role of prenatal smoking per se will be difficult to resolve using epidemiological studies.