Somatic gene therapy in gastroenterology: approaches and applications.
Somatic gene therapy in gastroenterology: approaches and applications.
复制标题
胃肠病学中的体细胞基因治疗：方法和应用。
DOI：
10.1097/00005176-199204000-00017
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发表时间：
1992
影响因子：
2.9
通讯作者：
Ledley,FD
中科院分区：
文献类型：
--
作者：
Ledley,FD
体细胞基因治疗代表了一种治疗多种遗传性和获得性疾病的新方法，在胃肠病学中有许多潜在的应用。体细胞基因治疗的基础是将重组基因高效地转移到体细胞组织中，如肝脏或肠道，并实现重组基因产物的表达。基因转移可以用来取代遗传缺陷的基因功能，或防止获得性或多因素疾病的进展。基因转移技术的治疗应用需要开发实现重组基因产品有效转移和表达的方法，研究旨在制定改变疾病过程的策略，以及旨在评估这种方法的技术可行性和治疗效果的临床研究。
SummarySomatic gene therapy represents a new approach for treating a variety of genetic and acquired diseases and has many potential applications in gastroenterology. Somatic gene therapy is based on the ability to transfer recombinant genes efficiently into somatic tissues, such as the liver or intestine, and achieve expression of the recombinant gene product. Gene transfer could be used to replace genetically defective gene functions or prevent the progression of acquired or multifactorial diseases. The therapeutic application of gene transfer technologies requires development of methods for achieving efficient transfer and expression of recombinant gene products, research directed at developing strategies for altering the course of disease, and clinical research aimed at assessing both the technical feasibility and therapeutic efficacy of this approach.