Tissue factor expression in rheumatoid synovium: a potential role in pannus invasion of rheumatoid arthritis
Tissue factor expression in rheumatoid synovium: a potential role in pannus invasion of rheumatoid arthritis
复制标题
类风湿滑膜中的组织因子表达：在类风湿关节炎血管翳侵袭中的潜在作用
DOI：
10.1016/j.acthis.2013.02.005
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发表时间：
2013-01-01
影响因子：
2.5
通讯作者：
Wang, Fengming
中科院分区：
文献类型：
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作者：
Chen, Lujun;Lu, Yahua;Wang, Fengming
类风湿关节炎（RA）的病理过程中，关节内血管生成以及血管翳的形成在关节软骨和骨的侵蚀中起着重要作用。组织因子（TF）是外源性凝血途径的重要起始因子，也参与RA进展的血管生成和血管翳形成。在本研究中，我们使用免疫荧光和共聚焦扫描方法来表征TF免疫定位在RA滑膜。结果表明，TF在RA滑膜细胞、CD 19（+）B细胞和CD 68（+）巨噬细胞中呈阳性表达，而在RA滑膜组织中，TF在新生血管的CD 34（+）内皮细胞、CD 3（+）T细胞和CD 14（+）单核细胞中呈弱阳性或阴性表达。我们的研究证实了TF在类风湿关节炎滑膜中的详细局部表达，并支持了这样的观点，即TF不仅由滑膜细胞本身表达，而且还由浸润的CD 19（+）B细胞和CD 68（+）巨噬细胞表达，参与了类风湿关节炎进展中的血管翳侵袭。(C)2013年爱思唯尔有限公司。All rights reserved.
Angiogenesis, as well as pannus formation within the joint, plays an important role in the erosion of articular cartilage and bone in the pathological process of rheumatoid arthritis (RA). Tissue factor (TF), an essential initiator of the extrinsic pathway of blood coagulation, is also involved in the angiogenesis and the pannus formation of RA progression. In the present study, we used immunofluorescence and confocal scanning methods to characterize TF immunolocalization in RA synovium. We showed that positive staining of TF could be immunolocalized in synoviocytes, CD19(+) B cells and CD68(+) macrophages, whereas weak or negative staining of tissue factor could be found in CD34(+) endothelial cells of neo-vessels, CD3(+) T cells and CD14(+) monocytes in RA synovium tissues. Our study demonstrates a detailed local expression of TF in the rheumatoid synovium, and supports the notion that TF, expressed not only by the synoviocytes themselves, but also the infiltrating CD19(+) B cells and CD68(+) macrophages, is involved in the pannus invasion in the progression of rheumatoid arthritis. (C) 2013 Elsevier GmbH. All rights reserved.