Morphogens and pattern formation
Morphogens and pattern formation
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DOI：
10.1002/bies.950190813
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发表时间：
1997-08-01
期刊：
影响因子：
4
通讯作者：
Cohen, S
中科院分区：
文献类型：
--
作者：
Neumann, C;Cohen, S
形态发生素梯度理论自本世纪开始以来就受到了相当大的欢迎，但形态发生素在控制多细胞发育中的作用的决定性证据一直难以捉摸。最近，对非洲爪蟾中的Activin和果蝇中的Wingless和Dpp这三种分泌信号蛋白的研究表明，这些蛋白具有形态发生素的功能。为了将一种因子定义为形态原，首先必须证明它对靶细胞有直接作用，其次必须证明它以浓度依赖性方式影响靶细胞的发育。考虑到这些标准，可用于各种建议形态发生剂的证据进行了讨论。虽然在所考虑的大多数情况下，证据并不确凿，但有一个强有力的证据支持上述三种蛋白质，这表明形态发生素在控制多细胞生物的发育方面具有潜在的普遍重要性。
Morphogen gradient theories have enjoyed considerable popularity since the beginning of this century, but conclusive evidence for a role of morphogens in controlling multicellular development has been elusive. Recently, work on three secreted signalling proteins, Activin in Xenopus, and Wingless and Dpp in Drosophila, has stongly suggested that these proteins function as morphogens. In order to define a factor as a morphogen, it is necessary to show firstly that it has a direct effect on target cells and secondly, that it affects the development of target cells in a concentration-dependent manner. With these criteria in mind, the evidence available for a variety of proposed morphogens is discussed. While the evidence is not conclusive in most of the cases considered, there is a strong case in favour of the three proteins mentioned above, which suggests that morphogens are potentially of general importance in controlling the development of multicellular organisms.