In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI.
In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI.
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DOI：
10.1016/s0960-894x(98)00380-1
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发表时间：
1998-08
影响因子：
2.7
通讯作者：
Z. Q. Xu;R. Buckheit;T. L. Stup;M. Flavin;A. Khilevich;J. Rizzo;L. Lin;D. Zembower
中科院分区：
文献类型：
--
作者：
Z. Q. Xu;R. Buckheit;T. L. Stup;M. Flavin;A. Khilevich;J. Rizzo;L. Lin;D. Zembower
评价了三种色满酮衍生物（+）-、（−）-和（±）-12-oxocalanetransA（2）对HIV和猴免疫缺陷病毒（SIV）的体外抗病毒活性。这些化合物被确定为HIV-1逆转录酶（RT）的抑制剂，并显示出对多种病毒的活性，这些病毒对其他HIV-1非核苷RT抑制剂具有抗性。它们是第一个报道的能够抑制SIV的calanestrin类似物。
The three chromanone derivatives, (+)-, (−)-, and (±)-12-oxocalanolide A (2), were evaluated for in vitro antiviral activities against HIV and simian immunodeficiency virus (SIV). The compounds were determined to be inhibitors of HIV-1 reverse transcriptase (RT) and exhibited activity against a variety of viruses selected for resistance to other HIV-1 nonnucleoside RT inhibitors. They are the first reported calanolide analogues capable of inhibiting SIV.