Allergic skin diseases
Allergic skin diseases
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DOI：
10.1016/j.jaci.2009.05.039
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发表时间：
2010-02-01
影响因子：
14.2
通讯作者：
Leung, Donald Y. M.
中科院分区：
文献类型：
--
作者：
Fonacier, Luz S.;Dreskin, Stephen C.;Leung, Donald Y. M.
皮肤是最大的免疫器官之一，受外部和内部因素以及先天性和适应性免疫反应的影响。许多皮肤病，如特应性皮炎、接触性皮炎、荨麻疹、血管性水肿、银屑病和自身免疫性起泡病，是免疫介导的。这些疾病大多是慢性的、炎症性的和增殖性的，其中遗传和环境因素都起着重要作用。这些免疫机制可能对未来治疗干预的潜在靶点产生影响。（J Allergy Clin Immunol 2010;125：S138-49.）
The skin is one of the largest immunologic organs and is affected by both external and internal factors, as well as innate and adaptive immune responses. Many skin disorders, such as atopic dermatitis, contact dermatitis, urticaria, angioedema, psoriasis, and autoimmune blistering disorders, are immune mediated. Most of these diseases are chronic, inflammatory, and proliferative, in which both genetic and environmental factors play important roles. These immunologic mechanisms might have implications for potential targets of future therapeutic interventions. (J Allergy Clin Immunol 2010;125:S138-49.)