Close correlation of liver stiffness with collagen deposition and presence of myofibroblasts in non-alcoholic fatty liver disease
Close correlation of liver stiffness with collagen deposition and presence of myofibroblasts in non-alcoholic fatty liver disease
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DOI：
10.1111/j.1872-034x.2011.00842.x
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发表时间：
2011-09-01
影响因子：
4.2
通讯作者：
Kawada, Norifumi
中科院分区：
文献类型：
--
作者：
Mori, Mami;Fujii, Hideki;Kawada, Norifumi
目的：非酒精性脂肪性肝病(NAFLD)肝纤维化程度与胶原沉积或肌成纤维细胞积聚的关系尚不清楚，瞬时弹性成像技术是一种快速、客观、可靠的肝纤维化分级方法。收集他们的临床资料和实验室数据。结果：瞬时弹性成像测量的肝脏硬度与Brunt‘s评分系统的组织病理纤维化分期相关(P=0.000149)。纤维化分期与天狼星红阳性面积(P=0.000032)和α-平滑肌肌动蛋白阳性面积(P=0.000898)的比值有关。最后，肝脏硬度与天狼星红阳性面积(r=0.390，P=0.0184)和α-平滑肌肌动蛋白阳性面积(r=0.333，P=0.0471)的比值显著相关。结论：瞬时弹性成像测量肝脏硬度对评估非酒精性脂肪肝纤维化进展有价值。
Aim: Transient elastography is known as a rapid, objective, and highly reliable technique for staging hepatic fibrosis caused by hepatitis C virus infection; however, the relationship between degree of fibrosis and the collagen deposition or the accumulation of myofibroblasts in non-alcoholic fatty liver disease (NAFLD) remains to be further elucidated.Methods: The subjects were 36 patients with NAFLD who received liver biopsy and liver stiffness measurement using transient elastography. Their clinical data and laboratory values were collected. Morphometric analyses of liver fibrosis indicated by collagen deposition and the relative numbers of myofibroblasts were performed.Results: Liver stiffness measured by transient elastography correlated with histopathological fibrosis staging of NAFLD determined by Brunt's scoring system (P = 0.000149). The fibrosis staging correlated with the ratios of the Sirius redpositive area (P = 0.000032) and alpha-smooth muscle actin-positive area (P = 0.000898). Finally, liver stiffness significantly correlated with the ratios of the Sirius red-positive area (r = 0.390, P = 0.0184) and alpha-smooth muscle actin-positive area (r = 0.333, P = 0.0471).Conclusions: Liver stiffness measurement by transient elastography is valuable for evaluating fibrotic progression in NAFLD.