Soluble receptor for advanced glycation end products in patients with decreased renal function
Soluble receptor for advanced glycation end products in patients with decreased renal function
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DOI：
10.1053/j.ajkd.2005.12.028
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发表时间：
2006-03-01
影响因子：
13.2
通讯作者：
Zima, T
中科院分区：
文献类型：
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作者：
Kalousová, M;Hodková, M;Zima, T
背景：晚期糖基化终产物（AGEs）在肾功能下降的患者中积累，并通过AGEs受体（RAGE）发挥各种毒性作用。可溶性RAGE （sRAGE）是一种天然存在的AGE-RAGE抑制剂。该研究的目的是描述sRAGE与肾功能和透析方式的关系。方法：研究对象为81例患者，其中有不同程度肾功能下降的患者25例，长期血液透析（HD）患者20例，腹膜透析（PD）患者15例，年龄匹配的健康受试者21例。采用免疫化学方法（酶联免疫吸附法）评估sRAGE，并采用经认证的方法测量常规生化参数。结果：sRAGE水平与血清肌酐浓度呈正相关(r=0.50
Background: Advanced glycation end products (AGEs) accumulate in patients with decreased renal function and exert various toxic effects through the receptor for AGEs (RAGE). Soluble RAGE (sRAGE) is a naturally occurring inhibitor of AGE-RAGE action. The aim of the study is to describe the relationship of sRAGE to renal function and dialysis modalities. Methods: The studied group consisted of 81 patients: 25 patients with various degrees of decreased renal function, 20 long-term hemodialysis (HD) patients, 15 peritoneal dialysis (PD) patients, and 21 healthy age-matched subjects. sRAGE was assessed immunochemically (enzyme-linked immunosorbent assay), and routine biochemical parameters were measured by means of certified methods. Results: sRAGE level correlates positively with serum creatinine concentration (r=0.50; P