Effect of quiet sleep on resting and CO2-stimulated breathing in humans.
Effect of quiet sleep on resting and CO2-stimulated breathing in humans.
复制标题
安静睡眠对人类休息和二氧化碳刺激呼吸的影响。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
N. Cherniack
中科院分区：
文献类型：
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作者：
B. Gothe;M. Altose;M. Goldman;N. Cherniack
我们研究了不同水平的吸入二氧化碳对健康成年人在清醒状态和第二阶段安静睡眠状态下的通风和呼吸模式的影响。在这两种状态下，受试者都被研究人员仰卧，头部围在遮阳篷里。潮气量(VT)是通过用磁力计定量测量腹部和肋骨的漂移来确定的。吸入的二氧化碳是通过将富含二氧化碳的气体混合到气流中而上升的，气流不断地冲刷着树冠。睡眠时，呼吸室内空气时，VT由410降至360毫升，呼吸频率亦由17次/分降至16次/分。结果，呼吸机通气量从6.5Torr/min降至5.8Torr/min，呼气末二氧化碳分压(PCO2)由39.1升至42.5Torr。平均而言，睡眠期间对二氧化碳的通风反应减少到清醒时的79%。在睡眠期间，二氧化碳产生的平均吸气流量的变化也较小。当睡眠期间呼吸室内空气时，清醒时和睡眠中对二氧化碳的呼吸反应与呼气末二氧化碳分压的升高呈负相关。在所有水平的室速中，安静睡眠时肋骨笼对室速的贡献大于清醒时。这些发现表明，安静的睡眠，除了令人沮丧的通风和对二氧化碳的反应外，还改变了通过肋骨和腹部移位获得室性心动过速的方式。
We examined the effects of different levels of inspired CO2 on ventilation and the pattern of breathing in healthy adults during the awake and the stage II quiet-sleep states. During both states, subjects were studied supine with their heads enclosed in a canopy. Tidal volume (VT) was determined from quantitative measurements of abdominal and rib cage excursions with magnetometers. Inspired CO2 was raised by blending CO2-enriched gas into the airflow, which continuously flushed the canopy. During sleep, while room air was breathed, VT decreased significantly from 410 to 360 ml, and respiratory rate also fell from 17 to 16 breaths/min. As a consequence, ventilation was significantly reduced from 6.5 to 5.8 l/min, and end-tidal CO2 partial pressure (PCO2) rose from 39.1 to 42.5 Torr. Ventilatory responses to CO2 were reduced, on the average, during sleep to 79% of waking levels. The change in average inspiratory flow produced by CO2 was also less during sleep. Waking and sleeping ventilatory responses to CO2 correlated inversely with the rise in end-tidal PCO2 when room air was breathed during sleep. At all levels of VT, the rib cage contribution to VT was greater during quiet sleep than during wakefulness. These findings suggest that quiet sleep, in addition to depressing ventilation and the response to CO2 alters the manner in which VT is attained by rib cage and abdominal displacements.