Models to Evaluate the Barrier Properties of Mucus During Drug Diffusion.
Models to Evaluate the Barrier Properties of Mucus During Drug Diffusion.
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DOI：
10.1016/j.ijpharm.2021.120415
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发表时间：
2021-02
影响因子：
5.8
通讯作者：
Liu Liu-Liu;Chun-ling Tian;Baoqi Dong;Meng-qiu Xia;Ye Cai;Rongfeng Hu;Xiaoqin Chu
中科院分区：
文献类型：
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作者：
Liu Liu-Liu;Chun-ling Tian;Baoqi Dong;Meng-qiu Xia;Ye Cai;Rongfeng Hu;Xiaoqin Chu
粘液广泛散布于鼻腔、口腔、呼吸道、眼睛、胃肠道、生殖道等，以防止致病菌和毒素的侵入。粘液层通过其持续分泌，可以阻止致病菌和毒素等大分子物质的通过，从而减少炎症的发生。毫无疑问，粘液也会阻碍口腔吸收。需要掌握肠粘液的生理和生化特性以及不同类型的粘液屏障模型。为了寻找提高药物生物利用度的方法，本文总结了粘液成分，屏障特性，粘液模型，粘膜粘附/mucopenetrating颗粒，以突出他们可以负担得起的信息，总的来说，审查旨在提供一个国家的最先进的路线图，为研究人员谁必须与这个关键的障碍，药物输送。
Mucus is widely disseminated in the nasal cavity, oral cavity, respiratory tract, eyes, gastrointestinal tract, and reproductive tract to prevent the invasion of pathogenic bacteria and toxins. The mucus layer through its continuous secretion can prevent the passage of macromolecular substances such as pathogenic bacteria and toxins, thereby reducing the occurrence of inflammation. Without a doubt, mucus also hinders oral absorption. The physiological and biochemical properties of intestinal mucus and the different types of mucus barrier models need to be predominated. To find ways to increase the bioavailability of drugs in the future, this article summarizes mucus composition, barrier properties, mucus models, and mucoadhesive/mucopenetrating particles to highlight the information they can afford.Collectively, the review seeks to provide a state-of-the-art roadmap for researchers who must contend with this critical barrier to drug delivery.