Risk of atrial fibrillation as a function of the electrocardiographic PR interval: Results from the Copenhagen ECG Study
Risk of atrial fibrillation as a function of the electrocardiographic PR interval: Results from the Copenhagen ECG Study
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DOI：
10.1016/j.hrthm.2013.04.012
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发表时间：
2013-09-01
期刊：
影响因子：
5.5
通讯作者：
Holst, Anders Gaarsdal
中科院分区：
文献类型：
--
作者：
Nielsen, Jonas Bille;Pietersen, Adrian;Holst, Anders Gaarsdal
研究背景PR间期延长与心房颤动(房颤)发病风险增加相关。目的探讨PR间期与房颤发病风险之间是否存在非线性关系。从2001年到2010年，这些人在一家全科医生的核心设施中记录了一张数字心电图仪。结果在平均5.7年的随访期内，11,087人发生房颤。PR间隔为95百分位数(女性为196毫秒，男性为204毫秒)与房颤风险增加相关，多变量调整后的风险比(HR)女性为1.18(95%可信区间[CI]1.06-1.30，P=.001)，男性为1.30(1.17-1.44，P<；.001)，与相应的参考组(PR区间在40至60个百分位数之间)相比，女性的多变量调整风险比(HR)为1.18(95%可信区间[CI]1.06-1.30，P=.001)。公关间隔短的
BACKGROUND Prolongation of the PR interval has been associated with an increased risk of incident atrial fibrillation (AF).OBJECTIVE To determine if there was a nonlinear relation between PR interval duration and the risk of AF.METHODS We included 288,181 individuals, corresponding to one third of the population in the greater region of Copenhagen. These individuals had a digital electrocardiogram (ECG) recorded in a general practitioner's core facility from 2001 to 2010. Data on drug use, comorbidity, and outcomes were collected from Danish registries.RESULTS During a median follow-up period of 5.7 years, 11,087 developed AF. Having a PR interval >= 95th percentile (>= 196 ms for women, >= 204 ms for men) was associated with an increased risk of AF as evidenced by a multivariable-adjusted hazard ratio (HR) of 1.18 (95% confidence interval [CI] 1.06-1.30, P = .001) for women and 1.30 (1.17-1.44, P < .001) for men compared with the respective reference groups (PR interval between 40th and 60th percentile). Having a short PR interval