Hypothalamic linkage in stress-induced hypocalcemia, gastric damage, and emotional behavior in rats.
Hypothalamic linkage in stress-induced hypocalcemia, gastric damage, and emotional behavior in rats.
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大鼠应激性低钙血症、胃损伤和情绪行为中的下丘脑联系。
DOI：
10.1152/ajpregu.1994.267.1.r38
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
N. Tashiro
中科院分区：
文献类型：
--
作者：
S. Aou;J. Ma;T. Hori;N. Tashiro
研究了下丘脑损伤对应激性低钙血症、胃损伤和游泳试验诱发行为的影响。与假手术组相比，损毁双侧下丘脑腹内侧核(VMH)可消除水束缚应激所致的低钙血症，减轻胃损伤。相比之下，与对照组大鼠相比，室旁核(PVN)的损伤加剧了应激性低钙血症和胃损伤。在强迫游泳实验中，VMH组大鼠的不动时间和挣扎持续时间分别比对照组大鼠短，而PVN组大鼠的不动时间和挣扎时间比对照组大鼠长。这些结果表明，VMH对应激性低钙血症、胃损伤和行为绝望有促进作用，而PVN有相反的作用。
The effects of hypothalamic lesions on stress-induced hypocalcemia, gastric damage, and swim test-evoked behavior were examined in rats. Bilateral lesions of the ventromedial nucleus in the hypothalamus (VMH) eliminated water-restraint stress-induced hypocalcemia and attenuated any gastric damage compared with those in the sham-operated rats. In contrast, lesions in the paraventricular nucleus (PVN) exacerbated both the stress-induced hypocalcemia and gastric lesions in comparison with those in the control rats. In a forced-swimming test, the VMH-lesioned rats showed a significantly shorter time of immobility as well as a longer duration of struggling than the control rats, respectively, while the PVN-lesioned animals spent a longer time in immobility and a shorter period struggling than the control rats. These results suggest that the VMH has an accelerative action in stress-induced hypocalcemia, gastric lesions, and behavioral despair, while the PVN has an opposite effect.