Cycling of gut mucosal CD4+T cells decreases after prolonged anti-retroviral therapy and is associated with plasma LPS levels
Cycling of gut mucosal CD4+T cells decreases after prolonged anti-retroviral therapy and is associated with plasma LPS levels
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DOI：
10.1038/mi.2009.129
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发表时间：
2010-03-01
影响因子：
8
通讯作者：
Sereti, I.
中科院分区：
文献类型：
--
作者：
Ciccone, E. J.;Read, S. W.;Sereti, I.
肠道粘膜是HIV免疫发病的重要部位，在急性感染期间发生严重的CD 4 + T细胞耗竭。长期抗逆转录病毒治疗（ART）对肠道T淋巴细胞循环和恢复的影响尚不清楚。从病毒血症、未经治疗、艾滋病毒感染的参与者、接受长期ART治疗（>5年）的患者和未感染的对照组中收集结肠和末端回肠活检和外周血样本，并通过流式细胞术进行分析。在肠道中，治疗患者中循环T细胞的比例降低，CD 4 + T细胞的数量正常化，与血液中CD 4 + T细胞上的β 7表达平行。病毒血症患者的肠道T细胞循环与血浆LPS水平升高相关，但与结肠HIV-RNA无关。这些数据表明，肠道T细胞活化和微生物易位可能是相互关联的，而延长ART可能会降低活化并恢复肠道CD 4 + T细胞。
The gut mucosa is an important site of HIV immunopathogenesis with severe depletion of CD4+ T cells occurring during acute infection. The effect of prolonged anti-retroviral therapy (ART) on cycling and restoration of T lymphocytes in the gut remains unclear. Colon and terminal ileal biopsies and peripheral blood samples were collected from viremic, untreated, HIV-infected participants, patients treated with prolonged ART (>5 years), and uninfected controls and analyzed by flow cytometry. In the gut, the proportion of cycling T cells decreased and the number of CD4+ T cells normalized in treated patients in parallel with beta 7 expression on CD4+ T cells in blood. Cycling of gut T cells in viremic patients was associated with increased plasma LPS levels, but not colonic HIV-RNA. These data suggest that gut T-cell activation and microbial translocation may be interconnected whereas prolonged ART may decrease activation and restore gut CD4+ T cells.