Event-related functional near-infrared spectroscopy (fNIRS) based on craniocerebral correlations: Reproducibility of activation?
Event-related functional near-infrared spectroscopy (fNIRS) based on craniocerebral correlations: Reproducibility of activation?
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DOI：
10.1002/hbm.20303
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发表时间：
2007-08-01
影响因子：
4.8
通讯作者：
Fallgatter, A. J.
中科院分区：
文献类型：
--
作者：
Plichta, M. M.;Herrmann, M. J.;Fallgatter, A. J.
本研究的目的是评估事件相关功能近红外光谱（fNIRS）检测大脑皮层激活的重测信度的基础上，颅脑的相关性。孤立的功能激活引起的运动皮层定期进行手指敲击任务。在44通道fNIRS记录期间，12名受试者在两个会话中进行了30次左右食指敲击试验。复检间隔设定为3周。简单的对比度t值的相关性，辅以散点图，通道组内相关系数（ICC），以及检测到的激活的大小和位置的再现性指数进行计算。组水平的结果显示足够的单次测量ICC（高达0.80）和良好的大小和位置的再现性（高达89%是可再现的）。会话间组振幅的比较表明，在重新测试研究设计中，fNIRS信号在一段时间内保持稳定：如果选择5%的α水平，显着差异的数量少于随机发生的假阳性激活通道。效应量分析表明，会话间振幅差异很小（平均值< 0.25）。对于脱氧血红蛋白和氧合血红蛋白，在激活对比基线对比度以及会话间振幅差异方面显示了不同的统计功效曲线，表明脱氧血红蛋白对局部血流动力学变化的灵敏度更高。结果表明，事件相关的fNfRS评估的感觉运动激活的基础上颅脑的相关性是足够的再现在组水平。
The purpose of the present study was to assess the retest reliability of cortical activation detected by event-related functional near-infrared spectroscopy (fNIRS) based on craniocerebral correlations. Isolated functional activation was evoked in the motor cortex by a periodically performed fingertapping task. During 44-channel fNIRS recording, 12 subjects performed 30 trials of right and left index finger tapping in two sessions. The retest interval was set to 3 weeks. Simple correlations of the contrast t-values supplemented by scatterplots, channel-wise intraclass correlation coefficients (ICC), as well as reproducibility indices for the size and the location of the detected activation were calculated. The results at the group level showed sufficient single measure ICCs (up to 0.80) and excellent reproducibility of the size and the location (up to 89% were reproducible). Comparisons of the intersession group amplitudes demonstrate that the fNIRS signals were stable across time in a retest study design: the number of significant differences was less than randomly occurring false-positive activated channels if an alpha level of 5% is chosen. Effect size analyses indicated that the intersession amplitude differences are small (mean < 0.25). For deoxyhemoglobin and oxyhemoglobin distinct statistical power profiles were revealed regarding the activation vs. baseline contrast as well as the intersession amplitude differences, indicating a higher sensitivity of deoxyhemoglobin for local hemodynamic changes. The results suggest that sensorimotor activation assessed by event-related fNfRS based on craniocerebral correlations is sufficiently reproducible at the group level.