sRAGE plays a role as a protective factor in the development of PCOS by inhibiting inflammation
sRAGE plays a role as a protective factor in the development of PCOS by inhibiting inflammation
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sRAGE 通过抑制炎症在 PCOS 的发展中发挥保护因子的作用
DOI：
10.1080/09513590.2019.1633297
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发表时间：
2019-06-27
影响因子：
2
通讯作者：
Guo, Yi-Hong
中科院分区：
文献类型：
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作者：
Wang, Bi-Jun;Qian, Li;Guo, Yi-Hong
摘要本研究旨在探讨外源性糖基化终末产物可溶性受体（sCRP）对多囊卵巢综合征（PCOS）患者卵泡细胞促炎活性的影响，并探讨其预防炎症发展的可能机制。将卵泡液分配到三个治疗组之一（0、0.6和1.2 μg mL-1 sRAGE）。总的来说，这些结果表明，外源性sodium补充剂通过调节p-ERK和AP-1信号转导来减轻卵巢卵泡颗粒细胞的炎症。
Abstract This study determined the effect of exogenous soluble receptor for advanced glycation end products (sRAGE) on the pro-inflammatory activities that occur during polycystic ovary syndrome (PCOS) in human follicular cells and explored a potential mechanism for preventing the development of inflammation. Follicular fluid was allocated into one of three treatment groups (0, 0.6, and 1.2 μg mL−1 of sRAGE). Collectively, these results indicate that exogenous sRAGE supplementation alleviates inflammation in ovarian follicular granulosa cells by regulating p-ERK and AP-1 signaling.