Dual mode selective chemosensor for copper and fluoride ions: a fluorometric, colorimetric and theoretical investigation
Dual mode selective chemosensor for copper and fluoride ions: a fluorometric, colorimetric and theoretical investigation
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DOI：
10.1039/c6dt00968a
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发表时间：
2016-01-01
影响因子：
4
通讯作者：
Guchhait, Nikhil
中科院分区：
文献类型：
--
作者：
Ghosh, Soumen;Ganguly, Aniruddha;Guchhait, Nikhil
含有芘的化学传感器即。 1 专为在互不干扰的双传感模式下高效、选择性地检测 Cu2+ 和 F(-) 离子而设计。 1 对 Cu2+ 的化学传感行为通过荧光、时间分辨荧光光谱和目视荧光颜色变化得到证明，对 F- 的化学传感行为则通过肉眼颜色变化、吸收和 H-1 NMR 滴定得到证明。化学传感器 1 通过准分子关闭机制对 Cu2+ 显示出优异的选择性。密度泛函理论 (DFT) 计算显示了 1 及其铜络合物 [1-Cu2+] 的结构和电子性质。对 F- 的选择性和敏感性通过 1 和 F- 之间的氢键相互作用以及 1 的去质子化来解释。1 的生物学应用已在 HEK 293 细胞中进行了评估，它在检测 Cu2+ 方面表现出良好的膜渗透性。该传感器还对牙膏中的氟化物表现出明显的敏感性。
A pyrene containing chemosensor viz. 1 has been designed for the efficient and selective detection of Cu2+ and F(-)ions in dual sensing mode which do not interfere with each other. The chemosensing behavior of 1 towards Cu2+ was demonstrated through fluorescence, time resolved fluorescence spectroscopy, and visual fluorescence colour changes, and towards F-through naked-eye colour changes, absorption and H-1 NMR titrations. The chemosensor 1 shows excellent selectivity towards Cu2+ through an excimer switch-off mechanism. Density Functional Theory (DFT) calculations were performed to show the structure and electronic properties of 1 and its copper complex [1-Cu2+]. The selectivity and sensitivity towards F-were explained in terms of H-bonding interactions between 1 and F-, then deprotonation of 1. The biological application of 1 has been evaluated in HEK 293 cells and it exhibits good membrane permeability for the detection of Cu2+. The sensor also shows appreciable sensitivity towards fluoride in toothpaste.