Oxygen-independent microbicidal mechanisms of phagocytes
Oxygen-independent microbicidal mechanisms of phagocytes
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DOI：
10.1111/paa.1999.111.5.390
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发表时间：
1999-09-01
期刊：
影响因子：
--
通讯作者：
Ganz, T
中科院分区：
文献类型：
--
作者：
Ganz, T
吞噬细胞的主要生物学功能是破坏入侵的微生物。在吞噬作用之后，微生物暴露于多种抗微生物物质，其复杂性从简单的氧自由基到大蛋白质不等。这些物质破坏各种微生物结构，最终杀死并消化大部分入侵者。本文综述了粒细胞和巨噬细胞中的氧非依赖性杀微生物机制。
The principal biological function of phagocytic cells is the destruction of invading microorganisms. Following phagocytosis, microbes are exposed to multiple antimicrobial substances ranging in complexity from simple oxygen radicals to large proteins. These substances disrupt various microbial structures and eventually kill and digest most of the invaders. This review is focused on oxygen-independent microbicidal mechanisms in granulocytes and macrophages.