Evaluation of Depression and Anxiety in a Diverse Population With Thyroid Eye Disease Using the Nationwide NIH All of Us Database.
Evaluation of Depression and Anxiety in a Diverse Population With Thyroid Eye Disease Using the Nationwide NIH All of Us Database.
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使用全国 NIH 所有人数据库对不同甲状腺眼病人群的抑郁和焦虑进行评估。
DOI：
10.1097/iop.0000000000002318
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发表时间：
2023
影响因子：
2
通讯作者：
Liu,CatherineY
中科院分区：
文献类型：
--
作者：
Lee,TonyaC;Radha-Saseendrakumar,Bharanidharan;Delavar,Arash;Ye,GordonY;Ting,MichelleA;Topilow,NicoleJ;Bass,Jeremy;Korn,BobbyS;Kikkawa,DonO;Baxter,SallyL;Liu,CatherineY
目的：评估甲状腺眼病（TED）患者抑郁和焦虑的患病率，并使用NIH All of Us database.Methods数据库确定社会人口统计学风险因素：将398例TED患者与1，592例对照组进行比较，这些对照组的人口统计学数据与2020年美国人口普查相匹配。主要结局为诊断为抑郁或焦虑;患者健康问卷-9（PHQ-9）评分和广泛性焦虑障碍-7（GAD-7）评分作为次要结局。结果：与对照组相比，TED患者更容易患抑郁症（OR 2.72，95%CI 2.08-3.56，p< 0.001）和焦虑症（OR 2.82，95%CI 2.16-3.70，p< 0.001）。在TED患者中，女性是抑郁（OR 1.72; 95%CI 1.00-5.07，p= 0.05）和焦虑（OR 2.17，95%CI 1.25-3.85，p= 0.006）的独立危险因素。失业（OR 1.72，95%CI 1.03-2.94，p= 0.04）和低收入（OR 0.88，收入作为连续变量，95%CI 0.79-0.99，p= 0.03）是焦虑的危险因素。PHQ-9评估的更严重抑郁症的危险因素包括较低的收入（OR 0.70，95%CI 0.57-0.85，p< 0.001），保护因素包括黑人（OR 0.12，95%CI 0.02-0.45，p= 0.002）。较低的收入与更严重的焦虑相关的评估GAD-7（OR 0.77，95%CI 0.64-0.94，p= 0.009）。结论：与对照组相比，TED患者更容易发展抑郁和焦虑。这项研究强调了TED的社会心理影响和相关的社会经济风险因素。
Purpose:To evaluate the prevalence of depression and anxiety among individuals with thyroid eye disease (TED) and identify sociodemographic risk factors using the NIH All of Us database.Methods:Three hundred ninety eight cases with TED were compared with 1,592 controls with demographics matching the 2020 US Census. Primary outcomes were diagnosed depression or anxiety; Patient Health Questionnaire-9 (PHQ-9) scores and General Anxiety Disorder-7 (GAD-7) scores were included as secondary outcomes. We performed multivariable logistic regression to generate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between TED and depression and anxiety.Results:Patients with TED were more likely to have depression (OR 2.72, 95% CI 2.08–3.56, p< 0.001) and anxiety (OR 2.82, 95% CI 2.16–3.70, p< 0.001) than controls. In patients with TED, female gender was an independent risk factor for both depression (OR 1.72; 95% CI 1.00–5.07, p= 0.05) and anxiety (OR 2.17, 95% CI 1.25–3.85, p= 0.006). Unemployment (OR 1.72, 95% CI 1.03–2.94, p= 0.04) and lower income (OR 0.88 for income as a continuous variable, 95% CI 0.79–0.99, p= 0.03) were risk factors for anxiety. Risk factors for more severe depression as assessed by PHQ-9 included lower income (OR 0.70, 95% CI 0.57–0.85, p< 0.001), and protective factors included Black race (OR 0.12, 95% CI 0.02–0.45, p= 0.002). Lower income was associated with more severe anxiety as assessed by GAD-7 (OR 0.77, 95% CI 0.64–0.94, p= 0.009).Conclusions:Patients with TED were more likely to develop depression and anxiety compared with controls. This study highlights the psychosocial impact of TED and associated socioeconomic risk factors.