Chemo-enzymatic routes towards the synthesis of bio-based monomers and polymers
Chemo-enzymatic routes towards the synthesis of bio-based monomers and polymers
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DOI：
10.1016/j.mcat.2019.01.036
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发表时间：
2019-04-01
影响因子：
4.6
通讯作者：
Scrutton, Nigel S.
中科院分区：
文献类型：
--
作者：
Ahmed, Syed T.;Leferink, Nicole G. H.;Scrutton, Nigel S.
定向进化和基因组测序的进步导致了具有新的和改进的催化性质的酶的发现和进化。制药业从这一点中受益匪浅，过去十年报告的出版物数量和生产工艺证明了这一点。然而，生物催化剂在聚合物工业中很少报道，这促使了这篇综述的撰写，以强调生产结构多样化单体的酶过程。这些重点详细介绍了酶在医疗、包装和涂层应用的聚合物合成中的工艺开发、演变和新用途。综述了氧化还原酶、转移酶、水解酶和裂解酶四类酶在合成商业和下一代生物可降解聚合物中的高价值单体中的应用。
Advancements in directed evolution and genome sequencing have led to the discovery and evolution of enzymes with new and improved catalytic properties. The pharmaceutical industry has greatly benefited from this, evidenced by the number of publications and manufacturing processes reported in the last decade. However, biocatalysts are rarely reported in the polymer industry which has prompted the writing of this review to highlight enzymatic processes towards the production of structurally diverse monomers. These highlights detail the process development, evolution and novel use of enzymes in polymer synthesis for medical, packaging and coating applications. The review features the use of four enzyme classes, oxidoreductases, transferases, hydrolases and lyases in the synthesis of high-value monomers found in commercial and next-generation biodegradable polymers.