Central Neural Circuits Orchestrating Thermogenesis, Sleep-Wakefulness States and General Anesthesia States.
Central Neural Circuits Orchestrating Thermogenesis, Sleep-Wakefulness States and General Anesthesia States.
复制标题
协调产热、睡眠-觉醒状态和全身麻醉状态的中枢神经回路
DOI：
10.2174/1570159x19666210225152728
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发表时间：
2022
影响因子：
5.3
通讯作者：
Mei, Wei
中科院分区：
文献类型：
--
作者：
Wu, Jiayi;Liu, Daiqiang;Li, Jiayan;Sun, Jia;Huang, Yujie;Zhang, Shuang;Gao, Shaojie;Mei, Wei
关键词：
在核心体温（Tcore）、睡眠-觉醒状态（SWs）和全身麻醉状态（GAs）的中枢神经回路（cnc）特异性识别方面取得了很大进展，主要是利用光遗传学或化学遗传学方法。我们总结了这三种cnc的神经元群和神经通路，为这三种cnc内部的协调以及不同环境光信号对这三种cnc的综合调控提供了证据。我们还概述了在CNCs-Tcore中起作用的一些瞬时受体电位（TRP）通道，并由一些全麻药物调节，这使得TRP通道可能成为解决全麻诱导的低体温（GAIH）的目标。我们认为这一综述将为进一步完善这些CNCs和阐明GAIH的核心机制提供新的方向。
Great progress has been made in specifically identifying the central neural circuits (CNCs) of the core body temperature (Tcore), sleep-wakefulness states (SWs), and general anesthesia states (GAs), mainly utilizing optogenetic or chemogenetic manipulations. We summarize the neuronal populations and neural pathways of these three CNCs, which gives evidence for the orchestration within these three CNCs, and the integrative regulation of these three CNCs by different environmental light signals. We also outline some transient receptor potential (TRP) channels that function in the CNCs-Tcore and are modulated by some general anesthetics, which makes TRP channels possible targets for addressing the general-anesthetics-induced-hypothermia (GAIH). We suggest this review will provide new orientations for further consummating these CNCs and elucidating the central mechanisms of GAIH.