Localized changes in immediate-early gene regulation during sensory and motor learning in zebra finches
Localized changes in immediate-early gene regulation during sensory and motor learning in zebra finches
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DOI：
10.1016/s0896-6273(00)80396-7
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发表时间：
1997-11-01
期刊：
影响因子：
16.2
通讯作者：
Clayton, DF
中科院分区：
文献类型：
--
作者：
Jin, H;Clayton, DF
一个复杂的神经系统控制着鸟鸣的学习，但它的组织尚不清楚，也不知道为什么学习只发生在青春期的关键时期。在这里，我们分析了zenk的斑胸草雀的发育调控，zenk是一个与记忆巩固有关的立即早期基因（IEG）。基础表达升高听觉端脑内（特别是，在尾内侧新纹状体[NCM]）在歌曲收购。表达可以进一步诱导歌曲播放孵化后30天，但不是在20天，也不是在青少年饲养在严重的隔离。唱歌本身会在歌曲产生核团（包括X区）中诱导zenk，即使在成年人中也是如此。然而，在原始纹状体（RA）的强健核的一个隔间内，这种反应随着歌唱的成熟而减弱。这些结果表明，在NCM的感觉记忆储存的发病可能受到部分调节，和运动可塑性可能在RA调节。
A complex neural system controls birdsong learning, but its organization is not understood, nor is it known why learning only occurs during a critical period in adolescence. Here, we analyzed developmental regulation in zebra finches of zenk, an immediate-early gene (IEG) implicated in memory consolidation. Basal expression was elevated within auditory telencephalon (specifically, within the caudomedial neostriatum [NCM]) during song acquisition. Expression could be further induced by song playbacks 30 days after hatching but not at 20 days nor in juveniles reared in severe isolation. Singing itself induced zenk in song production nuclei, including Area X, even in adults. Within a compartment of the robust nucleus of the archistriatum (RA), however, this response dwindled as singing matured. These results suggest that the onset of sensory memory storage may be regulated in part at NCM, and motor plasticity may be regulated at RA.