Physiological and pathological angiogenesis in the endocrine system
Physiological and pathological angiogenesis in the endocrine system
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DOI：
10.1002/jemt.10248
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发表时间：
2003-01-01
影响因子：
2.5
通讯作者：
Tóth, BE
中科院分区：
文献类型：
--
作者：
Góth, MI;Hubina, E;Tóth, BE
新血管的形成发生在许多生理状态（胚胎发育期间，女性生殖道的周期性变化）以及病理过程（如糖尿病视网膜病变和伤口愈合）中。在许多肿瘤类型中，血管生成已被证明与肿瘤形成、预后和对治疗的反应相关。在不同的内分泌肿瘤中，瘤内微血管可能与肿瘤行为或激素分泌有关。例如，侵袭性泌乳素腺瘤比非侵袭性腺瘤血管更多;手术方法在微血管密度较低的巨泌乳素腺瘤中更成功。在复发的甲状腺乳头状癌中发现了较多的微血管。微血管计数与甲状腺乳头状癌和髓样癌的预后之间存在相关性。已经鉴定了几种参与血管生成调节的刺激和抑制因子。其中，血管内皮生长因子（VEGF）已被证明是关键参与血管生成，也在实体瘤的新血管形成。多巴胺激动剂（已在临床上用于泌乳素瘤）对VEGF信号传导具有有效的抑制作用，因此可能是抗血管生成治疗的新工具。在绝大多数人垂体腺瘤中VEGF的分泌被地塞米松抑制。这表明，糖皮质激素可以考虑在某些垂体瘤的治疗。女性生殖道血管生成的周期性表明，刺激或抑制旁分泌血管生成因子可能会导致能够影响生殖内分泌疾病的新方法。还讨论了血管生成因子与内分泌系统肿瘤生长之间相互作用的实验和临床方面。(C)2003年威利-利斯。Inc.
Formation of new blood vessels occurs in many physiological states (during development of the embryo, cycling changes of the female reproductive tract), as well as in pathological processes (such as diabetic retinopathy and wound healing). Angiogenesis has been shown to be related to tumor formation, prognosis, and response to treatment in many tumor types. Intratumoral microvessels can be related to tumor behavior or hormone secretion in different endocrine tumors. For example, invasive prolactinomas are more vascular than noninvasive adenomas; a surgical approach is more successful in macroprolactinomas with lower microvessel density. A higher number of microvessels have been found in papillary thyroid carcinomas during recurrences. A correlation between microvessel count and prognosis in papillary and medullary thyroid carcinomas has been suggested. Several stimulating and inhibiting factors involved in the regulation of angiogenesis have been identified. Among them, vascular endothelial growth factor (VEGF) has been shown to be critically involved in angiogenesis and also in the neovascularization of solid tumors. Dopamine agonists (already in clinical use for prolactinomas) have potent inhibitory actions on VEGF signaling, and thus may be a new tool in antiangiogenic therapy. Secretion of VEGF in the great majority of human pituitary adenomas is inhibited by dexamethasone. This suggests that glucocorticoids can be considered in the treatment of certain pituitary tumors. The cyclic nature of angiogenesis in the female reproductive tract indicates that stimulation or inhibition of paracrine angiogenic factors may lead to new approaches for being able to influence reproductive endocrine disorders. Experimental and clinical aspects of interactions between angiogenic factors and tumor growth of the endocrine system are also discussed. (C) 2003 Wiley-Liss. Inc.