Long-term antibacterial effects and physical properties of a chlorhexidine-containing glass ionomer cement
Long-term antibacterial effects and physical properties of a chlorhexidine-containing glass ionomer cement
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DOI：
10.1111/j.1708-8240.2008.00146.x
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Brugger, Stefan
中科院分区：
文献类型：
--
作者：
Turkun, L. Sebnem;Turkun, Murat;Brugger, Stefan
问题陈述：世界上许多地区没有电、水，也没有能够使用牙科手机和旋转布尔斯治疗龋齿的牙科设施。对于在这些区域使用的修复技术，抗菌自粘玻璃离子材料将做出相当大的贡献。目的：本研究旨在测试双醋酸氯己定是否（Fluka BioChemika，布克斯，瑞士）-或氯己定二葡萄糖酸盐（Sigma-Aldrich，Steinheim，德国）-添加ChemFil的上级玻璃离子水门汀（Dentsply DeTrey，Konstanz，德国）的新制剂对某些口腔细菌具有任何长期抗菌作用，并测试新制剂的物理性质。ChemFil上级用作对照。将二醋酸氯己定（粉末）加入粉末中，并将二葡糖酸氯己定（液体）与粉末混合，以获得0.5%、1.25%和2.5%浓度的各组。根据ISO 9917-1测试凝固时间、抗压强度和酸侵蚀。还测定了加工时间、硬度、径向拉伸强度和双向弯曲强度。长期抗菌活性对S。变形湖L.嗜酸乳杆菌C.用琼脂扩散法检测白色念珠菌。结果：在对沙门氏菌的即时抗菌作用方面，两种药物的差异有统计学意义（P < 0.05）。变形杆菌，与对照组相比，所有测试组均显示菌株抑制（p < 0.05），高浓度组和所有二乙酸盐的区域更大。李斯特结果表明，与对照组相比，2.5%双乙酸酯组的抑菌效果最好。2.5%醋酸氯己定组对沙门氏菌的抗菌活性可达90天。对L.嗜酸乳杆菌试验组的工作时间和凝固时间、酸侵蚀试验、径向拉伸强度和双轴弯曲强度与对照组没有差异。然而，1.25%和2.5%的二醋酸氯己定组的抗压强度显著低于对照组。与对照组相比，0.5%和2.5%氯己定二葡萄糖酸盐组的硬度值较低。
Statement of the Problem: Many regions in the world do not have electricity, water, or access to dental facilities that allows the treatment of caries with dental handpieces and rotary burs. For restorative techniques used in these regions, an antibacterial self-adherent glass ionomer material would contribute considerably.Purpose: This study aimed to test if chlorhexidine diacetate (Fluka BioChemika, Buchs, Switzerland)- or chlorhexidine digluconate (Sigma-Aldrich, Steinheim, Germany)-added ChemFil Superior glass ionomer cement (Dentsply DeTrey, Konstanz, Germany) had any long-term antibacterial effect against certain oral bacteria and to test the new formulation's physical properties.Materials and Methods: ChemFil Superior was used as a control. Chlorhexidine diacetate (powder) was added to the powder and chlorhexidine digluconate (liquid) was mixed with the powder in order to obtain 0.5, 1.25, and 2.5% concentrations of the respective groups. Setting time, compressive strength, and acid erosion were tested according to ISO 9917-1. Working time, hardness, diametral tensile strength, and biaxial flexural strength were also determined. Long-term antimicrobial activity against S. mutans, L. acidophilus, and C. albicans were tested with the agar diffusion method. Analysis of variance (ANOVA) was used for comparison (p < 0.05).Results: Regarding the immediate antibacterial effect for S. mutans, all the tested groups showed inhibitions of the strain compared with the control group (p < 0.05), with larger zones for the higher concentration groups and all the diacetates. For L. acidophilus, all the groups were effective compared with the control, but the greatest antibacterial effect was observed with the 2.5% diacetate group. The 2.5% group of chlorhexidine diacetate showed antibacterial activity up to 90 days against S. mutans and up to 60 days against L. acidophilus. The working and setting time, acid erosion test, diametral tensile strength, and biaxial flexural strength of the tested groups were not different from the control ChemFil group. However, the 1.25 and 2.5% groups of chlorhexidine diacetate had significantly lower compressive strengths than the control group. Lower hardness values were obtained with the 0.5 and 2.5% chlorhexidine digluconate groups in comparison with the control group.