Modification by ozone of lung tumor development in mice.
Modification by ozone of lung tumor development in mice.
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臭氧对小鼠肺肿瘤发展的影响。
DOI：
10.1093/jnci/78.1.149
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Witschi,H
中科院分区：
文献类型：
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作者：
Last,JA;Warren,DL;Pecquet-Goad,E;Witschi,H
小鼠（A/J 品系或 Swiss Webster 品系）连续 18 周暴露于过滤空气或每天 8 小时的 0.4 或 0.8 ppm 臭氧中。每个测试组中的亚组在开始暴露方案前1天接受单次腹膜内注射1,000 mg尿素/kg或0.9%氯化钠媒介物。瑞士韦氏小鼠的肿瘤发生率在未接受尿素的组中为 0-3%，而在接受尿素的组中为 61-74%。在 A/J 小鼠中，相应的值分别为 9-38% 和 100%。暴露于臭氧导致两种品系的氨基甲酸酯处理小鼠中每个肺部的肿瘤数量减少，且呈剂量依赖性。在给予尿素加臭氧的 A/J 小鼠中，来自肺泡 II 型细胞的肿瘤似乎出现了特定的减少。也许最有趣的是，暴露于不含氨基甲酸酯的 0.8 ppm 臭氧的 A/J 小鼠中，每个肺部的肿瘤数量显着增加，这证实了其他人之前的报告。在瑞士韦伯斯特小鼠中没有观察到臭氧对肺肿瘤发展的相应影响。
Mice, either strain A/J or Swiss Webster, were exposed for 18 weeks either to filtered air or to 0.4 or 0.8 ppm ozone for 8 hours daily. Subgroups in each test group received a single ip injection of 1,000 mg urethan/kg or 0.9% sodium chloride vehicle 1 day prior to initiation of the exposure regimen. Tumor incidence in Swiss Webster mice was 0–3% in groups not receiving urethan and was 61–74% in groups receiving urethan. In A/J mice, the corresponding values were 9–38% and 100%, respectively. Exposure to ozone caused a decrease in the number of tumors per lung in urethan-treated mice of both strains, in a dose-dependent manner. There seemed to be a specific decrease in tumors derived from alveolar type II cells in the A/J mice given urethan plus ozone. Most interesting, perhaps, was a significant increase in the number of tumors per lung in A/J mice exposed to 0.8 ppm ozone without urethan, confirming a previous report by others. The corresponding ozone effect on lung tumor development was not observed in Swiss Webster mice.