Distinct patterns of apoptosis in the lung during liquid ventilation compared with gas ventilation
Distinct patterns of apoptosis in the lung during liquid ventilation compared with gas ventilation
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DOI：
10.1152/ajplung.00037.2001
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发表时间：
2002-07-01
影响因子：
4.9
通讯作者：
Davis, JM
中科院分区：
文献类型：
--
作者：
Mantell, LL;Shaffer, TH;Davis, JM
为了确定液体通气（LV）是否会导致更少的细胞损伤，并改善肺功能与传统的气体通气（GV）相比，我们分析了肺生理概况，肺组织学，和细胞死亡的110和120天的早产羔羊，随机接受任一通气方式的FIO2 = 1。LV肺扩张良好，肺功能充足，而GV动物表现出明显的肺不张，肺功能差，死亡率增加。两种诱导策略均诱导了显著的肺细胞凋亡，但具有不同的分布模式。虽然GV诱导的上皮细胞凋亡主要在衬里和管腔内的细支气管，LV诱导的显着的细胞凋亡更均匀地在整个肺实质，包括肺泡和间质空间。这些研究表明，尽管两种通气方式均引起局部细胞凋亡，但LV比GV更有效地输送氧气，并更均匀地招募肺。
To determine whether liquid ventilation (LV) causes less cell injury and improves lung function compared with conventional gas ventilation (GV), we analyzed pulmonary physiological profiles, lung histology, and cell death in 110- and 120-day preterm lambs, which were randomized to receive either ventilation modality on FIO2 = 1. LV lungs were well expanded with adequate pulmonary function, whereas GV animals exhibited marked atelectasis, poor pulmonary function, and increased mortality. Both ventilatory strategies induced marked lung cell apoptosis, but with distinct patterns of distribution. Although GV induced apoptosis of epithelium primarily in the lining and within the lumina of bronchioles, LV induced significant apoptosis much more homogeneously throughout lung parenchyma including alveoli and interstitial spaces. These studies suggest that although both forms of ventilation cause regional apoptosis, LV more effectively delivers oxygen and recruits the lung more homogeneously than GV.