Basal forebrain neurons provide major cholinergic innervation of primate neocortex.
Basal forebrain neurons provide major cholinergic innervation of primate neocortex.
复制标题
基底前脑神经元提供灵长类新皮质的主要胆碱能神经支配。
DOI：
10.1016/0304-3940(86)90193-x
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发表时间：
1986
影响因子：
2.5
通讯作者：
DeLong,MR
中科院分区：
文献类型：
--
作者：
Struble,RG;Lehmann,J;Mitchell,SJ;McKinney,M;Price,DL;Coyle,JT;DeLong,MR
在3只猴子基底核内注射伊博tenic酸，造成基底前脑病变。测定双侧多个新皮质回样本胆碱乙酰转移酶的活性。与对照半球相比，与病变同侧的新皮层酶活性降低了69%；此外，损伤部位和同侧皮质乙酰胆碱酯酶染色降低。这些结果支持了灵长类动物新皮层的主要胆碱能神经支配来源于基底前脑核周围神经元的轴突和神经末梢的概念，特别是基底核。
In 3 monkeys, lesions were made in the basal forebrain by microinjections of ibotenic acid into the nucleus basalis. Bilateral samples of multiple neocortical gyri were assayed for the activity of choline acetyltransferase. Compared to control hemispheres, enzyme activity was reduced up to 69% in the neocortex ipsilateral to the lesion; in addition, acetylcholinesterase staining was decreased at the lesioned site and in the ipsilateral cortex. These results support the concept that the principal cholinergic innervation of the primate neocortex is derived from axons and nerve terminals of neurons whose perikarya are located in the basal forebrain, particularly the nucleus basalis.