MITOCHONDRIAL-DNA ANALYSIS IN TIBET - IMPLICATIONS FOR THE ORIGIN OF THE TIBETAN POPULATION AND ITS ADAPTATION TO HIGH-ALTITUDE
MITOCHONDRIAL-DNA ANALYSIS IN TIBET - IMPLICATIONS FOR THE ORIGIN OF THE TIBETAN POPULATION AND ITS ADAPTATION TO HIGH-ALTITUDE
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DOI：
10.1002/ajpa.1330930204
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发表时间：
1994-02-01
影响因子：
2.8
通讯作者：
WALLACE, DC
中科院分区：
文献类型：
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作者：
TORRONI, A;MILLER, JA;WALLACE, DC
对居住在海拔3,000-4,500 m的54名藏族人的线粒体DNA(MtDNA)进行了聚合酶链式反应(PCR)扩增、高分辨限制性内切酶分析，并与其他10个亚洲和西伯利亚人的mtDNA进行了比较。这种比较表明，超过50%的亚洲mtDNA属于一个独特的mtDNA谱系，该谱系仅在蒙古人种中发现，这表明该谱系很可能起源于亚洲大陆人类殖民的早期阶段。在藏族mtDNA中，一组额外的连锁多态位点定义了相关mtDNA单倍型(单倍群)的7个次要谱系。这些单倍群在现代亚洲人群中的频率和分布支持了先前的遗传学证据，即藏族人虽然位于南亚，但与北方蒙古族人有着共同的祖先起源。这项对藏族线粒体DNA的分析还表明，线粒体DNA突变不太可能在藏族人适应高海拔地区的过程中发挥主要作用。(C)1994年Wiley-Liss，Inc.
Mitochondrial DNAs (mtDNAs) of 54 Tibetans residing at altitudes ranging from 3,000-4,500 m were amplified by polymerase chain reaction (PCR), examined by high-resolution restriction endonuclease analysis, and compared with those previously described in 10 other Asian and Siberian populations. This comparison revealed that more than 50% of Asian mtDNAs belong to a unique mtDNA lineage which is found only among Mongoloids, suggesting that this lineage most likely originated in Asia at an early stage of the human colonization of that continent. Within the Tibetan mtDNAs, sets of additional linked polymorphic sites defined seven minor lineages of related mtDNA haplotypes (haplogroups). The frequency and distribution of these haplogroups in modern Asian populations are supportive of previous genetic evidence that Tibetans, although located in southern Asia, share common ancestral origins with northern Mongoloid populations. This analysis of Tibetan mtDNAs also suggests that mtDNA mutations are unlikely to play a major role in the adaptation of Tibetans to high altitudes. (C) 1994 Wiley-Liss, Inc.