rs1800796 of the IL6 gene is associated with increased risk for anti-tuberculosis drug-induced hepatotoxicity in Chinese Han children
rs1800796 of the IL6 gene is associated with increased risk for anti-tuberculosis drug-induced hepatotoxicity in Chinese Han children
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DOI：
10.1016/j.tube.2018.05.011
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发表时间：
2018-07-01
期刊：
影响因子：
3.2
通讯作者：
Shen, Adong
中科院分区：
文献类型：
--
作者：
Li, Yingjia;Tang, Haijing;Shen, Adong
以往的研究已经揭示了免疫应答和氧化应激对抗结核药物诱导的肝毒性（ATDH）的发展的重要贡献。为探讨细胞因子基因白细胞介素6（IL 6）、氧化应激基因黄嘌呤脱氢酶/氧化酶（XO）和诱导型一氧化氮合酶（NOS 2）的单核苷酸多态性（SNP）是否与ATDH的易感性相关，我们对41例ATDH患儿和116例正常对照进行了病例对照研究。1 L 6基因rs 1800796等位基因在病例组和对照组中的分布差异有统计学意义，rs 1800796 G等位基因与ATDH的发病风险增加相关（OR：2.48，95%CI：1.40-4.40，P = 0.002）。经Bonferroni校正后，IL 6、XO和NOS 2基因的其他SNPs的等位基因和基因型分布在病例组和对照组之间差异无统计学意义。此外，所有选定的SNP之间没有发现相互作用。这些结果表明，IL 6基因的遗传变异可能有助于ATDH在中国汉族儿童人群的发展。
Previous studies have revealed the important contribution of the immune response and oxidative stress to the development of anti-tuberculosis drug-induced hepatotoxicity (ATDH). To investigate whether single-nucleotide polymorphisms (SNPs) of the cytokine gene interleukin-6 (IL6) and oxidative stress genes xanthine dehydrogenase/oxidase (XO) and inducible nitric oxide synthase (NOS2) were associated with susceptibility to ATDH, we performed a case-control study including 41 ATDH cases and 116 ATDH-free controls in Chinese Han children. Significant difference in the allele distribution of rs1800796 in the 1L6 gene was observed between the case and control groups, and the G allele of rs1800796 was associated with an increased risk for ATDH (odds ratio: 2.48, 95%CI: 1.40-4.40, P = 0.002). However, no significant difference was observed in the allele and genotype distributions of the other SNPs of the IL6, XO and NOS2 genes between the case and control groups after Bonferroni correction. In addition, no interaction was found between all selected SNPs. These findings indicate that genetic variants of the IL6 gene might contribute to the development of ATDH in the Chinese Han pediatric population.