Cerebellar benzodiazepine receptor distribution: an autoradiographic study of the normal C57BL/6J and Purkinje cell degeneration mutant mouse.
Cerebellar benzodiazepine receptor distribution: an autoradiographic study of the normal C57BL/6J and Purkinje cell degeneration mutant mouse.
复制标题
小脑苯二氮卓受体分布：正常 C57BL/6J 和浦肯野细胞变性突变小鼠的放射自显影研究。
DOI：
10.1016/0304-3940(86)90258-2
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发表时间：
1986
影响因子：
2.5
通讯作者：
Frostholm,A
中科院分区：
文献类型：
--
作者：
Rotter,A;Frostholm,A
用光镜放射自显影技术研究了正常小鼠和蒲肯野细胞变性突变小鼠小脑内[~3H]氟硝基安定结合部位的分布。在正常小鼠的小脑皮质，[~3H]氟硝西潘在分子层上呈高密度结合，在浦肯野细胞层上呈中等密度，在颗粒细胞层上呈低密度结合，白质内无标记。小脑深部核团标记为中等密度。在54天龄的浦肯野细胞变性突变体小脑中，观察到小脑皮质的标记密度降低了36%。分子细胞层和颗粒细胞层的密度都降低了大致相同的量；然而，小脑深层核团的标记显著增加。
The distribution of [3H]flunitrazepam binding sites in the cerebella of normal mice and Purkinje cell degeneration mutant mice was studied by light microscopic autoradiography. In the cerebellar cortex of normal mice, a high density of [3H]flunitrazepam binding was observed over the molecular layer, an intermediate density over the Purkinje cell layer and a low density over the granule cell layer; the white matter was devoid of labeling. The deep cerebellar nuclei were labeled to an intermediate density. In the 54-day-old Purkinje cell degeneration mutant cerebellum, which is depleted of Purkinje cells, a 36% reduction in labeling density of the cerebellar cortex was observed. The density was reduced by approximately equal amounts in both the molecular and granule cell layers; labeling in the deep cerebellar nuclei was, however, substantially increased.