An enhanced fractal self-pumping dressing with continuous drainage for accelerated burn wound healing.
An enhanced fractal self-pumping dressing with continuous drainage for accelerated burn wound healing.
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DOI：
10.3389/fbioe.2023.1188782
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发表时间：
2023
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
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烧伤创面大量分泌的渗出物往往会延迟愈合过程，并伴有不希望的粘连、持续炎症和高感染风险。传统敷料的排液能力有限，不能有效地清除过多的渗出液，而是将其限制在浸湿的敷料中，使其浸没创面。本文通过在水凝胶前驱体中漂浮和聚集中空玻璃微球，制备了一种增强型分形自泵敷料，该敷料能够以不下降的高速持续排水，并有效地促进烧伤创面愈合。小的空心玻璃微球可以将分形微通道分裂成更小的具有更高分形维数的微通道，从而导致更高的吸收效率。在小鼠背部活体烧伤模型中，增强型分形自泵敷料可以显着减少伤口面积的外观，并沿着愈合过程减轻组织水肿。本研究为临床应用设计高效和连续引流敷料提供了依据。
Massive exudates oversecreted from burn wounds always delay the healing process, accompanied by undesired adhesion, continuous inflammation, and high infection risk. Conventional dressings with limited draining ability cannot effectively remove the excessive exudates but constrain them in the wetted dressings immersing the wound bed. Herein, we fabricate an enhanced fractal self-pumping dressing by floating and accumulating hollow glass microspheres in the hydrogel precursor, that can continuously drain water at a non-declining high speed and effectively promote burn wound healing. Small hollow glass microspheres can split the fractal microchannels into smaller ones with higher fractal dimensions, resulting in higher absorption efficiency. In an in vivo burn wound model on the dorsum of murine, the enhanced fractal self-pumping dressing can significantly reduce the appearance of the wound area and alleviate tissue edema along the healing process. This study sheds light on designing high-efficiency and continuous-draining dressings for clinical applications.