Synthesis and evaluation of 1-position-modified inositol 1,4, 5-trisphosphate analogs
Synthesis and evaluation of 1-position-modified inositol 1,4, 5-trisphosphate analogs
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DOI：
10.1016/s0960-894x(99)00256-5
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发表时间：
1999-06-21
影响因子：
2.7
通讯作者：
Nagano, T
中科院分区：
文献类型：
--
作者：
Inoue, T;Kikuchi, K;Nagano, T
通过在1-位上修饰磷酸合成IP 3类似物，并通过表面等离子体共振测量分析它们对IP 3受体的亲和力。我们的研究结果表明，连接到这个位置的疏水性和带电部分增强了对IP 3受体的亲和力。(C)1999爱思唯尔科技有限公司。保留所有权利。
IP3 analogs were synthesized by the modification of phosphate at the 1-position, and their affinity for the IP3 receptor was analyzed by means of surface plasmon resonance measurements. Our results suggest that a hydrophobic and charged moiety linked to this position enhances the affinity for the IP3 receptor. (C) 1999 Elsevier Science Ltd. All rights reserved.