A tantalum electrode coated with graphene nanowalls for simultaneous voltammetric determination of dopamine, uric acid, L-tyrosine, and hydrochlorothiazide
A tantalum electrode coated with graphene nanowalls for simultaneous voltammetric determination of dopamine, uric acid, L-tyrosine, and hydrochlorothiazide
复制标题
涂有石墨烯纳米墙的钽电极，用于同时伏安法测定多巴胺、尿酸、L-酪氨酸和氢氯噻嗪
DOI：
10.1007/s00604-017-2154-y
复制
发表时间：
2017-06-01
影响因子：
5.7
通讯作者：
Yang, Baohe
中科院分区：
文献类型：
--
作者：
Tian, Fangyuan;Li, Hongji;Yang, Baohe
作者描述了一种伏安传感器，用于同时测定多巴胺（DA），尿酸（UA），L-酪氨酸（Tyr）和利尿药氢氯噻嗪（HCTZ）。该测定基于使用沉积在钽基底上的石墨烯微球。通过扫描电子显微镜、透射电子显微镜、X射线衍射、电化学阻抗谱和循环伏安法对样品进行了表征。通过直流电弧等离子体喷射化学气相沉积法在衬底上垂直生长纳米颗粒。示出的修饰电极，使同时差分脉冲伏安法测定DA，UA，Tyr，和HCTZ。石墨烯微球显示出大的比表面积、高电导率和大量用于氧化分析物的催化活性位点。同时检测的最佳pH值为7.0，峰电位为0.124 V（vs.SCE）DA，0.256 V UA，0.536 V Tyr和0.708 V HCTZ。相应的检测限为0.04 μ M、0.1 μ M、0.6 μ M和0.4 μ M。结果表明，这种石墨烯壁修饰电极是一个有前途的工具，灵敏度，选择性和稳定的sensors.Graphical abstractionThe石墨烯基差分脉冲伏安传感器同时测定多巴胺，尿酸，L-酪氨酸，氢氯噻嗪具有高选择性，灵敏度和稳定性的设计。
The authors describe a voltammetric sensor for simultaneous determination of dopamine (DA), uric acid (UA), L-tyrosine (Tyr), and the diuretic drug hydrochlorothiazide (HCTZ). The assay is based on the use of graphene nanowalls deposited on a tantalum substrate. The nanowalls are characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, electrochemical impedance spectroscopy, and cyclic voltammetry. The nanowalls are vertically grown on the substrate by direct-current arc plasma jet chemical vapor deposition. The modified electrode is shown to enable simultaneous differential pulse voltammetric determination of DA, UA, Tyr, and HCTZ. The graphene nanowalls display a large specific surface, high conductivity, and a large number of catalytically active sites for oxidation of analytes. Simultaneous detection is performed best at a pH value of 7.0 and at peak potentials of 0.124 V (vs. SCE) for DA, 0.256 V for UA, 0.536 V for Tyr and 0.708 V for HCTZ. The respective detection limits are 0.04 μM, 0.1 μM, 0.6 μM and 0.4 μM. The results show that this graphene wall modified electrode is a promising tool for the design of sensitive, selective, and stable sensors.Graphical abstractThe graphene-based differential pulse voltammetric sensor for simultaneous determination of dopamine, uric acid, L-tyrosine, and hydrochlorothiazide exhibits high selectivity, sensitivity, and stability.