Differential susceptibility of human lymphocyte cultures to infection by HIV.
Differential susceptibility of human lymphocyte cultures to infection by HIV.
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人类淋巴细胞培养物对 HIV 感染的不同易感性。
DOI：
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发表时间：
1987
影响因子：
4.6
通讯作者：
L. Fitz‐Gibbon
中科院分区：
文献类型：
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作者：
M. Wainberg;N. Blain;L. Fitz‐Gibbon
我们评估了HIV感染来自不同健康供体的外周血淋巴细胞培养物的能力，这些供体的年龄在20岁至76岁之间。结果表明，所有这些人的细胞都可以被感染，尽管感染细胞的百分比因情况而异。当尝试感染来自同一供体的细胞超过一次时，观察到类似的变化。在大多数情况下，HIV感染导致活化细胞状态持续存在，如细胞表面存在Tac Ag或IL-2受体所示。HIV感染的淋巴细胞与未感染的细胞共孵育不影响后者对植物血凝素（PHA）或表达Tac Ag的能力。
We have assessed the ability of HIV to infect cultures of peripheral blood lymphocytes derived from different healthy donors, varying in age between 20 and 76. The results indicate that cells from all of these people can be infected, although the percentage of infected cells varied from case to case. A similar variation was observed when attempts were made to infect cells from the same donor on more than one occasion. In most cases, infection by HIV led to persistence of an activated cell state, as indicated by the presence of Tac Ag or IL-2 receptor, at the cell surface. Co-incubation of HIV-infected lymphocytes with uninfected cells did not affect the ability of the latter either to respond to phytohaemagglutinin (PHA) or to express Tac Ag.