Oxidative stress in athletes during extreme endurance exercise
Oxidative stress in athletes during extreme endurance exercise
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DOI：
10.1016/s0891-5849(01)00667-0
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发表时间：
2001-10-01
影响因子：
7.4
通讯作者：
Traber, MG
中科院分区：
文献类型：
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作者：
Mastaloudis, A;Leonard, SW;Traber, MG
尽管运动对健康有许多已知的好处，但有大量证据表明，耐力运动与氧化应激有关。为了确定极限耐力运动是否会导致脂质过氧化，对11名运动员(3名女性，8名男性)在1个月后的50公里超级马拉松(试验1)和久坐(试验2)中进行了研究。每次试验的前一晚，受试者在晚餐时分别摄入75毫克的d(3)-RRR和d(6)-所有RAC-α-生育酚醋酸酯。在试验2的基线、赛前30min、赛中、赛后、赛后1h、赛后24h和相应的时间采集血液。所有I I受试者都完成了比赛，平均跑步时间为391+/-23min。血浆F-2-异前列腺素从赛前的75+/-7pg/ml上升到赛后的131+/-17(p<；0.02)，然后在赛后24小时恢复到基线水平；F-2-异前列腺素在试验2期间保持不变。与久坐试验(2.3×10(-4)0.2×10(-4)；p<；.03)相比，比赛中的氢化α-生育酚消失率更快(2.8×10(-4)+/-0.2×10(-4)；p<；.03)。这些数据表明，极端耐力运动会导致脂质过氧化的产生，并伴随着维生素E消失的增加。(C)2001年爱思唯尔科学公司。
Despite the many known health benefits of exercise, there is a body of evidence suggesting that endurance exercise is associated with oxidative stress. To determine whether extreme endurance exercise induces lipid peroxidation, 11 athletes (3 females, 8 males) were studied during a 50 km ultramarathon (trial 1) and during a sedentary protocol (trial 2) 1 month later. The evening before each trial, with dinner, subjects consumed 75 mg each d(3)-RRR and d(6)-all rac-alpha -tocopheryl acetates. Blood was obtained at baseline, 30 min pre-race, mid-race, post-race, 1 h post-race, 24 h post-race, and at corresponding times during trial 2. All I I subjects completed the race; average run time was 391 +/- 23 min. Plasma F-2-isoprostanes increased from 75 +/- 7 pg/ml at pre-race to 131 +/- 17 (p < .02) at post-race, then returned to baseline at 24 h post-race; F-2-isoprostanes were unchanged during trial 2. Deuterated alpha -tocopherol disappearance rates were faster (2.8 X 10(-4) +/- 0.2 X 10(-4)) during the race compared to the sedentary trial (2.3 X 10(-4) 0.2 X 10(-4); p < .03). These data suggest that extreme endurance exercise results in the generation of lipid peroxidation with a concomitant increase in vitamin E disappearance. (C) 2001 Elsevier Science Inc.