Pivotal advance: High-mobility group box 1 protein - a cytokine with a role in cardiac repair
Pivotal advance: High-mobility group box 1 protein - a cytokine with a role in cardiac repair
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DOI：
10.1189/jlb.0306165
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发表时间：
2007-01-01
影响因子：
5.5
通讯作者：
Capogrossi, Maurizio C.
中科院分区：
文献类型：
--
作者：
Germani, Antonia;Limana, Federica;Capogrossi, Maurizio C.
核蛋白高迁移率族蛋白1（HMGB 1）在很大程度上是其在炎症中的作用。然而，由炎症细胞以及坏死细胞释放的HMGB1也可以作为组织损伤的信号，并通过将干细胞募集到损伤部位来参与组织修复。HMGB1作为一种在组织再生中发挥积极作用的分子，其功能的出现引起了人们的关注。我们最近证明，在心肌梗死小鼠模型中给予HMGB1可激活心脏干细胞并促进其分化为心肌细胞。再生效应导致心脏功能的改善。在这篇综述中，我们强调了HMGB1的有益作用，并讨论了以生长因子为基础的心肌梗死治疗方法。
The nuclear protein high-mobility group box 1 (HMGB 1) has been largely characterized for its role in inflammation. However, HMGB1 released by inflammatory cells, as well as by necrotic cells, may also act as a signal of tissue damage and participate in tissue repair by recruiting stem cells to the injury site. The emergence of this function has focused the interest on HMGB1 as a molecule,smith an active role in tissue regeneration. We recently demonstrated that HMGB1 administration in a mouse model of myocardial infarction activates cardiac stem cells and promotes their differentiation into cardiomyocytes. The regenerative effect results in the improvement of cardiac function. In this review, we highlight the beneficial role of HMGB1 and discuss growth factor-based therapeutic approaches for the treatment of myocardial infarction.