Cutting edge: Lectin-like transcript 1 is a ligand for the CD161 receptor
Cutting edge: Lectin-like transcript 1 is a ligand for the CD161 receptor
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DOI：
10.4049/jimmunol.175.12.7791
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发表时间：
2005-12-15
影响因子：
4.4
通讯作者：
Braud, VM
中科院分区：
文献类型：
--
作者：
Aldemir, H;Prod'homme, V;Braud, VM
人类NK细胞和T细胞亚群或NKT细胞表达功能未知的孤儿c型凝集素受体CD161 （NKR-P1A）。与具有多个编码激活或抑制受体的NKR-P1基因的啮齿动物相比，人类单一NKR-P1A受体传递信号的性质仍有待阐明。在这篇文章中，我们证明了凝集素样转录物1 （LLT1）分子是CD161受体的配体。CD161与靶细胞上表达的LLT1结合在NK细胞上，可抑制NK细胞介导的细胞毒性和ifn - γ分泌。相反，在TCR信号存在下，LLT1/CD161相互作用增强T细胞产生ifn - γ。这些发现确定了一种新的配体/受体对差异调节NK细胞和T细胞的功能。
Human NK cells and subsets of T cells or NKT cells express the orphan C-type lectin receptor CD161 (NKR-P1A) of unknown function. In contrast to rodents that possess several NKR-P1 genes coding for either activating or inhibitory receptors, the nature of signals delivered by the single human NKR-P1A receptor is still to be clarified. In this article, we show that the lectin-like transcript 1 (LLT1) molecule is a ligand for the CD161 receptor. Engagement of CD161 on NK cells with LLT1 expressed on target cells inhibited NK cell-mediated cytotoxicity and IFN-gamma secretion. Conversely, LLT1/CD161 interaction in the presence of a TCR signal enhanced IFN-gamma production by T cells. These findings identify a novel ligand/receptor pair that differentially regulate NK and T cell functions.