Autoimmune Reactivity in Graft Injury: Player or Bystander?
Autoimmune Reactivity in Graft Injury: Player or Bystander?
复制标题
DOI：
10.1007/s40472-015-0068-3
复制
发表时间：
2015-09-01
影响因子：
2.1
通讯作者：
Burlingham, William J
中科院分区：
文献类型：
--
作者：
Agashe, Vrushali V;Burlingham, William J
器官移植是唯一可行的治疗几个终末期器官衰竭。然而，慢性排斥阻止了移植物的长期存活。传统上，这种排斥反应归因于移植患者中同种异体免疫的发展。然而，最近的证据表明，自身免疫在某些器官移植的慢性排斥反应中起着比同种免疫更大的作用。在这篇综述中，我们将集中在实体器官移植中的自身免疫的历史，并在看胶原V型，K-α-微管蛋白，波形蛋白，心肌肌球蛋白和热休克蛋白作为经典的例子，在器官移植中的自身抗原。我们还将研究一些最近的报告，研究自身免疫的机制，并试图为自身免疫中的一些古老问题提供答案。
Organ transplantation is the only viable treatment for several end-stage organ failures. However chronic rejection prevents long-term graft survival. Traditionally this rejection was attributed to the development of alloimmunity in transplant patients. However recent evidence suggests that autoimmunity plays a larger role in chronic rejection of certain organ transplants, than alloimmunity. In this review we will focus on the history of autoimmunity in solid-organ transplantation and at look the Collagen Type V, K-alpha-tubulin, Vimentin, Cardiac myosin and Heat Shock Proteins as classical examples of auto-antigens in organ transplantation. We will also look at some of the recent reports looking at the mechanisms of autoimmunity and try to provide answers to some of the age-old questions in autoimmunity.