Effect of Royal Jelly on spatial learning and memory in rat model of streptozotocin-induced sporadic Alzheimer's disease.
Effect of Royal Jelly on spatial learning and memory in rat model of streptozotocin-induced sporadic Alzheimer's disease.
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DOI：
10.4103/2277-9175.98150
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发表时间：
2012
影响因子：
1
通讯作者：
Pilehvarian AA
中科院分区：
文献类型：
--
作者：
Zamani Z;Reisi P;Alaei H;Pilehvarian AA
最近有研究表明，蜂王浆(RJ)对神经功能有好处。阿尔茨海默病(AD)与学习和记忆障碍有关。因此，本研究旨在观察RJ对侧脑室注射链脲佐菌素(ICV-STZ)后大鼠空间学习记忆的影响。大鼠双侧脑室注射链脲佐菌素，而假手术组大鼠只接受赋形剂。用含RJ的食物(3%w/w)(冻干RJ与普通食物粉混合)或普通食物喂养大鼠10天。用Morris水迷宫测试大鼠的空间学习记忆能力。结果表明，与假手术组相比，ICV-STZ组大鼠的潜伏期和路径长度明显增加，且ICV-STZ大鼠对平台先前所在的目标象限的记忆能力降低；而服用含RJ食物的STZ组大鼠的潜伏期和路径长度受到明显保护。我们的发现支持RJ的潜在神经保护作用及其对AD的帮助作用。
It has been recently demonstrated that Royal jelly (RJ) has a beneficial role on neural functions. Alzheimer's disease (AD) is associated with impairments of learning and memory. Therefore, the present study was designed to examine the effect of RJ on spatial learning and memory in rats after intracerebroventricular injection of streptozotocin (icv-STZ). Rats were infused bilaterally with an icv injection of STZ, while sham rats received vehicle only. The rats were feed with RJ-contained food (3% w/w) (lyophilized RJ mixed with powdered regular food) or regular food for 10 days. Then spatial learning and memory was tested in the rats by Morris water maze test. Results showed that in icv-STZ group latency and path length were increased as compared to sham group, also icv-STZ rats less remembered the target quadrant that previously the platform was located; however, these were protected significantly in STZ group that received RJ-containing food. Our findings support the potential neuroprotective role of RJ and its helpful effects in AD.