Oxygen content of transmembrane proteins over macroevolutionary time scales
Oxygen content of transmembrane proteins over macroevolutionary time scales
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DOI：
10.1038/nature05450
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发表时间：
2007-01-04
期刊：
影响因子：
64.8
通讯作者：
Collins, Sinead
中科院分区：
文献类型：
--
作者：
Acquisti, Claudia;Kleffe, Juergen;Collins, Sinead
我们观察到细胞区域化的出现时间与大气中的氧浓度有关。为了探索这种相关性，我们预测并描述了19个分类群中所有跨膜蛋白的拓扑结构，并将拓扑结构上的差异与历史上的大气氧浓度相关联。在这里，我们证明了跨膜蛋白，单独的和作为一个群体，可能选择性地排除了古代祖先分类群中的氧，并且随着时间的推移，当大气中的氧水平上升时，这种限制减少了。随着这种限制的减少，与通讯相关的跨膜蛋白的大小和数量增加。我们提出的假设是，大气中的氧浓度通过限制跨膜通信所需的结构域的大小来影响细胞分区化的进化时间。
We observe that the time of appearance of cellular compartmentalization correlates with atmospheric oxygen concentration. To explore this correlation, we predict and characterize the topology of all transmembrane proteins in 19 taxa and correlate differences in topology with historical atmospheric oxygen concentrations. Here we show that transmembrane proteins, individually and as a group, were probably selectively excluding oxygen in ancient ancestral taxa, and that this constraint decreased over time when atmospheric oxygen levels rose. As this constraint decreased, the size and number of communication-related transmembrane proteins increased. We suggest the hypothesis that atmospheric oxygen concentrations affected the timing of the evolution of cellular compartmentalization by constraining the size of domains necessary for communication across membranes.