Biomimetic treatment on dental implants for short-term bone regeneration
Biomimetic treatment on dental implants for short-term bone regeneration
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DOI：
10.1007/s00784-013-0953-z
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发表时间：
2014-01-01
影响因子：
3.4
通讯作者：
Ginebra, Maria-Pau
中科院分区：
文献类型：
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作者：
Javier Gil, Francisco;Manzanares, Norberto;Ginebra, Maria-Pau
这项工作的主要目的是评估新型骨传导植入物的短期骨再生潜力。这项研究的新颖之处在于，在小型猪模型中植入种植体后，在很短的时间内分析了一种新颖的两步处理的有效性，该两步处理结合了喷丸和热化学处理。将经过四种不同表面处理（即生物活化表面、微粗糙喷砂、微粗糙酸蚀刻和光滑加工钛植入物）的三百二十个植入物放入20只小型猪的骨骼中。种植体植入后 3 天、1、2、3 和 10 周通过组织形态计量学分析确定骨与种植体接触的百分比。分析了种植体样本的表面成分、形貌和润湿性。与第 3 天到第 3 周之间的所有其他处理相比，喷丸和热化学处理的结合加速了早期骨再生（p < 0.05）。第 2 周获得的骨整合值一直保持到实验结束，没有任何显着变化（直接接触百分比千分之一欧元 85%）。这主要归因于这些种植体能够在体内形成一层磷灰石矿物，覆盖种植体，并能快速刺激种植体表面的骨成核和生长。这种对 cpTi 的处理所产生的表面质量为牙种植体提供了独特的快速骨再生和骨整合的能力。这种处理代表着在减少种植体加载前时间的方向上向前迈出了一步。
The main purpose of this work was to assess the short-term bone regenerative potential of new osteoconductive implants. The novelty of the study lies in the analysis of the effectiveness of a novel two-step treatment which combines shot-blasting with a thermo-chemical treatment, at very short times after implant placement in a minipig model.Three hundred twenty implants with four different surface treatments, namely bioactivated surfaces, micro-rough grit-blasted, micro-rough acid-etched and smooth as-machined titanium implants were placed into the bone of 20 minipigs. The percent of bone-to-implant contact was determined 3 days, 1, 2, 3 and 10 weeks after implant placement by histomorphometric analysis. Surface composition, topography and wettability of the implant specimens were analysed.The combination of shot-blasting and thermo-chemical treatment accelerated bone regeneration at early stages in comparison with all other treatments between day 3 and week 3 (p < 0.05). The value of osseointegration attained at week 2 was maintained until the end of the experiment without any significant changes (percent direct contact a parts per thousand aEuro parts per thousand 85 %). This was mostly attributed to the ability of these implants to form in vivo a layer of apatitic mineral that coated the implant and could rapidly stimulate bone nucleation and growth from the implant surface.The surface quality resulting from this treatment on cpTi provided dental implants with a unique ability of rapid bone regeneration and osseointegration.This treatment represents a step forward in the direction of reducing the time prior to implant loading.