Local heating, but not indirect whole body heating, increases human skeletal muscle blood flow
Local heating, but not indirect whole body heating, increases human skeletal muscle blood flow
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DOI：
10.1152/japplphysiol.00269.2011
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发表时间：
2011-09-01
影响因子：
3.3
通讯作者：
Crandall, Craig G.
中科院分区：
文献类型：
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作者：
Heinonen, Ilkka;Brothers, R. Matthew;Crandall, Craig G.
Heinonen I, Brothers RM, Kemppainen J, Knuuti J, Kalliokoski KK, Crandall CG。局部加热，而不是间接的全身加热，会增加人体骨骼肌的血流量。中国生物医学工程学报（英文版），2011；首次发表于2011年6月16日；doi: 10.1152 / japplphysiol.00269.2011。几十年来，人们一直认为直接加热和间接加热（后者在不直接加热被评估区域的情况下提高血液和核心温度）会增加皮肤的血流量，但不会增加骨骼肌的血流量。然而，最近的研究结果表明，腿部被动加热可能会增加肌肉血流量。利用正电子发射断层扫描技术，本研究验证了直接和间接加热都会增加肌肉血流量的假设。在恒温基线、右小腿局部加热（仅右小腿暴露于热源（水灌注服））和左小腿不暴露于热源的间接全身热应激期间，对8名受试者的小腿肌肉和皮肤血流量进行评估。局部加热使右小腿肌内温度从33.4 +/- 1.0℃升高到37.4 +/- 0.8℃，肠道温度没有变化。这种刺激使肌肉血流量从1.4 +/- 0.5毫升增加到2.3 +/- 1.2毫升。min(-1) (P < 0.05)，皮肤血流量由0.7 +/- 0.3 ml.100 g (1).min(1)增加至5.5 +/- 1.5 ml.100 g (1).min (1) （P < 0.01）。虽然全身热应激使肠道温度升高约1℃，但在全身热应激期间，未直接暴露于水灌注服（即间接加热）的小腿肌肉血流量并未增加(常温：1.6 +/- 0.5 ml.100 g(-1).min(-1)；热应力：1.7±0.3 ml.100 g(-1).min(-1)；P = 0.87)。然而，全身加热反射性地增加了小牛皮肤血流量（至4.0 +/- 1.5 ml.100 g(-1)）。最小（-1）)在不暴露于水灌注服的区域。这些数据表明，局部而非间接的加热会增加人体小腿骨骼肌的血流量。这些结果对重新考虑先前接受的全身热应激期间的血流分布具有重要意义。
Heinonen I, Brothers RM, Kemppainen J, Knuuti J, Kalliokoski KK, Crandall CG. Local heating, but not indirect whole body heating, increases human skeletal muscle blood flow. J Appl Physiol 111: 818-824, 2011. First published June 16, 2011; doi: 10.1152/japplphysiol.00269.2011.-For decades it was believed that direct and indirect heating (the latter of which elevates blood and core temperatures without directly heating the area being evaluated) increases skin but not skeletal muscle blood flow. Recent results, however, suggest that passive heating of the leg may increase muscle blood flow. Using the technique of positron-emission tomography, the present study tested the hypothesis that both direct and indirect heating increases muscle blood flow. Calf muscle and skin blood flows were evaluated from eight subjects during normothermic baseline, during local heating of the right calf [only the right calf was exposed to the heating source (water-perfused suit)], and during indirect whole body heat stress in which the left calf was not exposed to the heating source. Local heating increased intramuscular temperature of the right calf from 33.4 +/- 1.0 degrees C to 37.4 +/- 0.8 degrees C, without changing intestinal temperature. This stimulus increased muscle blood flow from 1.4 +/- 0.5 to 2.3 +/- 1.2 ml.100 g(-1).min(-1) (P < 0.05), whereas skin blood flow under the heating source increased from 0.7 +/- 0.3 to 5.5 +/- 1.5 ml.100 g (1).min (1) (P < 0.01). While whole body heat stress increased intestinal temperature by similar to 1 degrees C, muscle blood flow in the calf that was not directly exposed to the water-perfused suit (i.e., indirect heating) did not increase during the whole body heat stress (normothermia: 1.6 +/- 0.5 ml.100 g(-1).min(-1); heat stress: 1.7 +/- 0.3 ml.100 g(-1).min(-1); P = 0.87). Whole body heating, however, reflexively increased calf skin blood flow (to 4.0 +/- 1.5 ml.100 g(-1).min(-1)) in the area not exposed to the water-perfused suit. These data show that local, but not indirect, heating increases calf skeletal muscle blood flow in humans. These results have important implications toward the reconsideration of previously accepted blood flow distribution during whole body heat stress.